Publications by authors named "Toshiki Okadome"
Article Synopsis
- This case study discusses monozygotic twin sisters who both have hereditary spastic paraplegia type 4 (SPG4) and epilepsy, with only one twin diagnosed with narcolepsy type 1 (NT1).
- The sister with NT1 displayed symptoms like excessive daytime sleepiness and cataplexy, along with low orexin levels.
- They both carry specific genetic markers and a new mutation in the spastin gene, and this case highlights how environmental factors may play a role in the development of NT1, given that the other twin does not have the condition.
Background: We previously demonstrated the usefulness of periorbital electrodes in supplemental recording to detect epileptiform discharges in patients with mesial temporal lobe epilepsy (MTLE). However, eye movement may disturb periorbital electrode recording. To overcome this, we developed mandibular (MA) and chin (CH) electrodes and examined whether these electrodes could detect hippocampal epileptiform discharges.
View Article and Find Full Text PDFPurpose: Interictal epileptic discharges (IEDs) are known to affect cognitive function in patients with epilepsy, but the mechanism has not been elucidated. Sleep spindles appearing in synchronization with IEDs were recently demonstrated to impair memory consolidation in rat, but this has not been investigated in humans. On the other hand, the increase of sleep spindles at night after learning is positively correlated with amplified learning effects during sleep for motor sequence learning.
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- The study investigates how the morphology of hippocampal subfields relates to long-term memory performance in patients with focal epilepsy, focusing on accelerated long-term forgetting (ALF).
- Researchers assessed memory through testing and MRI on 80 epilepsy patients and 30 healthy controls, finding that certain hippocampal regions relate to memory retention over time.
- Results indicate that atrophy in the CA1 region of the left hippocampus is linked to decreased verbal memory retention, suggesting a specific area of the hippocampus plays a critical role in long-term memory in these patients.
Article Synopsis
- The case study focuses on a patient whose seizures were triggered by a specific movement during shadowboxing, characterized by a sequence of focal aware seizures and head turning.
- The researchers used video-electroencephalographic recordings to pinpoint the triggering motion, allowing the patient to continue boxing by avoiding it, while suggesting that understanding these triggers may help minimize exercise restrictions for affected individuals.
It remains unclear whether epileptogenic networks in focal epilepsy develop on physiological networks. This work aimed to explore the association between the rapid spread of ictal fast activity (IFA), a proposed biomarker for epileptogenic networks, and the functional connectivity or networks of healthy subjects. We reviewed 45 patients with focal epilepsy who underwent electrocorticographic (ECoG) recordings to identify the patients showing the rapid spread of IFA.
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