The Current Role of Stereotactic Body Radiation Therapy (SBRT) in Hepatocellular Carcinoma (HCC).

The role of stereotactic body radiotherapy (SBRT), which can deliver high radiation doses to focal tumors, has greatly increased in not only early-stage hepatocellular carcinoma (HCC), but also in portal vein or inferior vena cava thrombi, thus expanding this therapy to pre-transplantation and the treatment of oligometastases from HCC in combination with immune checkpoint inhibitors (ICI). In early-stage HCC, many promising prospective results of SBRT have been reported, although SBRT is not usually indicated as a first treatment potion in localized HCC according to several guidelines. In the treatment of portal vein or inferior vena cava tumor thrombi, several reports using various dose-fraction schedules have shown relatively good response rates with low toxicities and improved survival due to the rapid advancements in systemic therapy.

Stereotactic body radiation therapy for metastatic lung metastases.

Although systemic therapy is standard management for patients with metastatic disease, several recent reports have indicated that an addition of local therapies including stereotactic body radiation therapy (SBRT) for patients with oligometastatic disease (OMD) could improve survival. The lung is the most common site of distant metastasis from many solid tumors, and the strategy of SBRT, such as dose-fraction schedules, timing, etc., would be different depending on the type of primary tumor, location, and patterns of OMD.

Nonmechanical transverse scanning laser Doppler velocimeter using wavelength change.

A transverse scanning laser Doppler velocimeter (LDV) that does not require any moving mechanism in its sensor probe is proposed, and the scanning function is demonstrated theoretically and experimentally. In the proposed scanning LDV, the measurement position is transversely scanned on the basis of a wavelength change induced by a tunable laser and a combination of a grating and a Dove prism. To demonstrate the scanning function in the transverse direction, an experiment was carried out using a setup of the sensor probe consisting of bulk optical components.