Publications by Toshikazu Nagatsuna

Publications by authors named "Toshikazu Nagatsuna"

J Neuroendovasc Ther

September 2021

A rare case of an 88-year-old woman with a ruptured dissecting aneurysm in the posterior communicating artery and chronic kidney disease was reported.
The patient experienced sudden headaches and vomiting due to subarachnoid hemorrhage, and treatment involved endovascular embolization using only 10 mL of diluted contrast medium.
Post-surgery, the patient had a successful recovery with no worsening of kidney function, highlighting that minimal contrast can be safely used in similar cases.

J Neurosurg Case Lessons

March 2021

- A rare case of an idiopathic dissecting cerebral aneurysm (IDCA) was diagnosed in a healthy 7-month-old boy after he experienced seizures; this type of aneurysm is typically male-dominant and uncommon in children, especially in the distal anterior cerebral artery (ACA).
- The boy underwent emergency surgery to extract the ruptured aneurysm, with intraoperative imaging confirming blood flow, and pathology revealed characteristics typical of IDCA without any recognizable cause.
- This case highlights the effectiveness of using indocyanine green videoangiography during surgery and marks the first reported instance of an IDCA in the distal ACA in an infant, contributing to the medical understanding of this rare condition.

Cerebrovasc Dis

April 2005

- This study examined how argatroban, a drug that inhibits thrombin, impacts brain swelling and inflammation in rats after a simulated intracerebral hemorrhage (ICH) induced by collagenase IV injections.
- Administering argatroban significantly decreased brain edema from 44.6 microliters to 14.3 microliters within 72 hours and also reduced the infiltration of harmful immune cells such as polymorphonuclear leukocytes and monocytes/macrophages.
- Notably, argatroban did not increase the size of the hematoma, suggesting its effectiveness in limiting secondary brain damage due to edema and inflammation in the ICH rat model.