Publications by authors named "Toshikazu Koiwai"
Acne vulgaris is a complex condition involving factors that affect the pilosebaceous unit. A primary manifestation of acne pathology is the development of comedones, often linked to the overproduction of sebum resulting from 5α-dihydrotestosterone (5α-DHT) and insulin activity. Ozenoxacin is a topical quinolone that exhibits potent antibacterial activity against Cutibacterium acnes (C.
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- NIR radiation, found in sunlight and linked to skin aging, is shown to promote sebaceous gland enlargement and skin thickening in hamsters.
- The study reveals that this enlargement results from an increase in sebocyte proliferation, evidenced by higher levels of specific proteins (PCNA and lamin B1).
- Additionally, NIR exposure boosts epidermal growth factor receptor (EGFR) production in sebocytes through a process that involves reactive oxygen species (ROS), with hydrogen peroxide further enhancing EGFR mRNA levels.
Sebaceous gland cells (sebocytes) differentiate to intracellularly accumulate lipid droplets - a phenomenon similar to that found in adipocytes. In the present study, we examined whether the regulation of lipogenesis in sebocytes is the same as that in preadipocytes. When sebocytes and preadipocytes, prepared from auricle and subcutaneous adipose tissues from the inguinal region of hamsters, respectively, were treated with a common differentiation inducer, insulin, intracellular lipid-droplet formation and triacyglycerol (TG) production were dose- and time-dependently augmented in both.
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