Publications by authors named "Toshihisa Nosaka"
Article Synopsis
- The study aimed to determine how cytokine mRNA expression is affected by artificial perfusate or ischemia-reperfusion (I/R) in an isolated rat lung model.
- Rats underwent a procedure where the left pulmonary artery was occluded for 60 minutes and then reperfused for 30 minutes, while constant ventilation and perfusion were maintained.
- Results showed increased vascular permeability and significant changes in cytokine mRNA expression in the I/R lung, with a particular trend based on whether low-endotoxin (LE) or standard (ST) perfusate was used, indicating complex inflammatory responses.
Recipients for liver transplantation often have portosystemic shunts due to portal hypertension. It is an important problem whether such shunts should be ligated during operations. Ligating the shunts seems of benefit for increasing portal blood flow to the liver, but it is sometimes difficult technically, and it is invasive to the patient.
View Article and Find Full Text PDFExcessive nitric oxide (NO) production has been implicated to be responsible for the development of septic shock. To determine whether plasma nitrite/nitrate (NOx) levels are related to the severity of systemic inflammatory response syndrome (SIRS) and the degree of multiple organ dysfunction, we studied plasma NOx levels in 70 patients with SIRS consisting of noninfectious SIRS (n = 32), sepsis (n = 23), and septic shock (n = 15). Infection is a microbial phenomenon characterized by an inflammatory response to the presence of microorganism.
View Article and Find Full Text PDFObjectives: To test the hypotheses (1) that nitric oxide (NO) production is stimulated after cardiovascular surgery and is related to the hyperdynamic state and (2) that NO production is more prominent in patients with cardiopulmonary bypass.
Design: Prospective, clinical study.
Setting: Intensive care unit in a university hospital.
Objective: To verify the hypothesis that the gastric intraluminal PCO2 (PgCO2) changes independently of the change in cardiac output (CO) during and after cardiovascular surgery using cardiopulmonary bypass (CPB), and that the elevation of PgCO2 affects the patients' morbidity.
Design: Prospective, noninterventional study.
Setting: Medical/surgical intensive care unit and operating theater of a university hospital.