Publications by authors named "Toshihiro Sakata"
Article Synopsis
- Natural killer (NK) cells are crucial for immune defense in the liver, and this study investigates potential markers for improving their function in patients with hepatocellular carcinoma (HCC).
- The research found that aging affects NK cell characteristics, and higher levels of ILT2 on NK cells from HCC patients correlate with lower cytotoxic abilities.
- The study suggests that targeting the MIF-CXCR4 interaction could help restore the functionality of ILT2-positive NK cells, making ILT2 a potential target for cancer immunotherapy.
Article Synopsis
- NASH (non-alcoholic steatohepatitis) can lead to serious liver conditions like cirrhosis and HCC, and although exercise is known to suppress inflammation in acute liver issues, its effects on chronic liver disease progression are less clear.
- In an experiment, mice were divided into control and NASH groups, with some remaining sedentary and others exercising for 12 weeks; various liver and immune responses were then analyzed.
- Results indicated that while NASH led to increased liver damage and chronic inflammation, exercise significantly reduced these effects and changed immune cell profiles, suggesting that physical activity plays a protective role against the progression of NASH.
Backgrounds And Aims: Toll-like receptor (TLR) agonists have been developed as adjuvants to efficiently induce antiviral immune responses. Specificity and potency of these compounds are essential requirements for clinical trial applications. In patients with hepatitis B virus (HBV) infections, sustained loss of hepatitis B surface antigen (HBsAg) is a therapeutic goal, which may be achievable by the sequential activation of follicular helper T cells (Tfh) and antibody-secreting B cells.
View Article and Find Full Text PDFRecently, several reports demonstrated the efficacy of neoadjuvant chemotherapy (NAC) or chemoradiotherapy (NACRT) for patients with borderline resectable (BRPC) and locally advanced unresectable pancreatic carcinoma (LAPC). The aim of this study was to evaluate the treatment response after NACRT, especially for nerve plexuses, and the optimal resection area for superior mesenteric artery nerve plexuses in BRPC and LAPC patients after NACRT.A total of 17 patients with BRPC and LAPC received preoperative gemcitabine-based NACRT.
View Article and Find Full Text PDFIntraductal papillary mucinous neoplasms (IPMNs) are characterized by the papillary proliferation of atypical mucinous epithelial cells in the pancreatic ductal system. There are two recurrence patterns following resection of IPMNs: Metachronous multifocal occurrence of IPMNs, and distinct pancreatic ductal adenocarcinoma (PDAC) in the remnant pancreas. Several recent studies investigated the development of distinct PDAC during follow-up evaluation of IPMNs and the incidence rate ranged from 4.
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