Publications by authors named "Toshihiko Uemura"
Article Synopsis
- Western high-fat diets (HFD) are linked to an increased risk of prostate cancer, with studies on genetically modified mice showing that HFD promotes inflammation and tumor growth.
- The gut microbiome's composition changes due to HFD, which affects the host's immune response; it was found that high levels of histamine and increased mast cells are associated with larger prostate tumors in HFD-fed mice.
- Treatment with fexofenadine, an antihistamine, reduced tumor growth by affecting immune cell types and signaling pathways, suggesting that targeting gut microbiota and histamine signaling might be potential strategies for managing HFD-related prostate cancer.
αvβ8 is an integrin that recognizes an Arg-Gly-Asp (RGD) motif and interacts with fibronectin, vitronectin, and latent TGF-β1. We comprehensively determined the binding activity of the αvβ8 integrin toward 25 secreted proteins having an RGD motif. The αvβ8 integrin strongly bound to latent TGF-β1 but showed marginal activity for other RGD-containing proteins, including fibronectin and vitronectin.
View Article and Find Full Text PDFIntegrin alpha8beta1 interacts with a variety of Arg-Gly-Asp (RGD)-containing ligands in the extracellular matrix. Here, we examined the binding activities of alpha8beta1 integrin toward a panel of RGD-containing ligands. Integrin alpha8beta1 bound specifically to nephronectin with an apparent dissociation constant of 0.
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