A Novel Direct Puncture Cannulation Blood Pump Support System: in Vivo Experimental Proof of Concept for a Therapeutic Approach with Cardiac Arrest.

The rate of out-of-hospital cardiac arrest is increasing according to the changes in the proportion of ages in super-aged society. We developed a novel transcutaneous cannulation-type mechanical circulatory system for an alternative therapeutic approach to cardiac arrest using a small centrifugal blood pump. We proposed a transcutaneous mechanical circulatory support capable of rapid installation and quick start of circulatory support for recovery after cardiac arrest by left ventricular direct puncture using the Seldinger technique.

Effects of Surface Roughness on Mechanical Hemolysis.

Previous in vitro hemolysis test results showed that an inlet taper or a round corner in the leading edge of a stenotic connector played an important role in the reduction of hemolysis. However, computational fluid dynamics (CFD) analysis of these results indicated that the shear rate and hemolysis level were not always related to each other. Then, further research was performed, focusing on the effects of surface roughness on hemolysis.