Publications by authors named "Toshifumi Takahashi"

Background: In freeze-thawed embryo transfer (FET) cycles, hormone replacement treatment (HRT) is crucial for implantation and pregnancy maintenance. HRT typically continues until the 10th week of pregnancy owing to a luteoplacental shift, although a definitive HRT regimen remains undetermined. We present the case of a woman who underwent FET during an HRT cycle and ceased HRT after a negative pregnancy test at 3 weeks and 5 days, who went on to deliver a healthy baby.

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Introduction And Hypothesis: Pelvic organ prolapse (POP) affects approximately 30% of middle-aged and older women, with 11%-19% requiring surgical intervention. Laparoscopic sacrocolpopexy preserves the vaginal axis and length but involves a steep learning curve and longer operation times. Robotic sacrocolpopexy (RSC) addresses these issues, offering enhanced surgical precision.

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Although some studies have reported kidney transplantation for end-stage kidney disease after hematopoietic stem cell transplantation, few have reported kidney transplantation after ABO-incompatible hematopoietic stem cell transplantation. In this report, we describe a case of kidney transplantation after major ABO-incompatible HSCT and reviewed previous reports of kidney transplantation after hematopoietic stem cell transplantation. A 21-year-old male patient received major ABO-incompatible hematopoietic stem cell transplantation from an unrelated donor for B-lymphoblastic lymphoma.

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  • Acute Sheehan syndrome is a rare form of hypopituitarism that can develop after significant postpartum hemorrhage, as seen in a 37-year-old woman who lost 3,000 mL of blood following a vulvar hematoma.
  • The patient presented with symptoms like anorexia and fatigue 28 days after giving birth, and MRI results confirmed swelling of the pituitary gland due to hemorrhage.
  • This case is unique as it links acute Sheehan syndrome to vulvar hematoma, emphasizing the need to consider less common complications in severe postpartum bleeding cases.
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  • * Intraoperative elastography was used during surgery to ensure complete removal of the adenomyotic tissue while protecting the endometrium, with MRI confirming no remaining adenomyosis post-surgery.
  • * The patient achieved a successful twin delivery via cesarean section after IVF, signaling the potential of elastography-guided surgery for enhancing fertility in women with adenomyosis, though more research is needed to confirm its effectiveness and safety.
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  • Japan has reported cases of Buruli ulcer (BU), a rare disease caused by Mycobacterium ulcerans subsp. shinshuense, dating back to 1982, with an increase in cases, especially in the last decade.
  • Out of 87 total reported cases to date, 50 occurred within the last ten years, indicating a rising trend.
  • The country's advanced healthcare system aids in the investigation and treatment of BU, but a lack of awareness among medical professionals often leads to delayed diagnoses, highlighting the need for increased education and awareness efforts.
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Background: Robotic simple hysterectomy (RSH) is the most common robotic gynecologic surgery in the United States. Uterine manipulators are commonly used to handle the uterus during laparoscopic surgery, but few studies have examined their necessity in RSH. This study retrospectively compares RSH cases with and without the use of manipulators, and identifies predictors for their intraoperative use.

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Pregnancy- and lactation-associated osteoporosis (PLO) is a rare type of premenopausal osteoporosis, typically occurring during the third trimester of pregnancy and the early postpartum lactation period. This report presents a case involving severe multiple vertebral fractures due to PLO with low bone mineral density (BMD) and heightened bone turnover. A 39-year-old primiparous Japanese woman reported low back pain (LBP) starting at 28 weeks of pregnancy.

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This study evaluated the effects of docetaxel and androgen receptor signaling inhibitors as second-line treatments in patients with castration-resistant prostate cancer after androgen receptor signaling inhibitors as first-line treatment. This study retrospectively evaluated the clinical outcomes of second-line treatment with docetaxel or androgen receptor signaling inhibitor in patients with castration-resistant prostate cancer who received first-line treatment with androgen receptor signaling inhibitors. Clinical backgrounds and outcomes were compared between docetaxel and androgen receptor signaling inhibitors as second-line treatment.

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Objective: Prevention of subsequent primary cancer (SPC) is crucial for cancer survivors, particularly those who developed the disease during childhood, adolescence, and young adulthood (CAYA). The aim of this study was to assess the current status of SPC prevention among female CAYA cancer survivors.

Methods: A survey regarding long-term health issues after cancer treatment was conducted using questionnaires that targeted women aged ≥20 years who had developed cancer before the age of 40 years.

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An 81-year-old man with prostate cancer (cT3aN0M0), who had been undergoing hormonal therapy for 4 years and had maintained low prostate specific antigen levels, developed metastasized pelvic lymph nodes. A tissue biopsy revealed neuroendocrine differentiation of prostate cancer in the metastatic lymph nodes. Consequently, chemotherapy with carboplatin+etoposide was initiated.

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Oxidative stress (OS) affects men's health and impairs spermatogenesis. Micronutrient antioxidants are available for male infertility as complemental support; however, their efficacy remains debatable. This study aimed to investigate whether antioxidants can help to reduce sperm OS and improve semen analysis and quality.

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  • * A case study of a 39-year-old Japanese woman revealed that her right ureter had serious issues, including a complete absence of flow and kidney atrophy, due to an undetected congenital abnormality.
  • * This case highlights the importance of recognizing both normal pelvic anatomy and potential embryological abnormalities to minimize surgical complications in hysterectomy procedures.
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  • Women with polycystic ovary syndrome (PCOS) have a higher risk of gestational diabetes mellitus (GDM), particularly depending on their pre-pregnancy body mass index (BMI).
  • A study in Japan assessed this risk using data from nearly 93,000 singleton pregnancies, finding that women with PCOS showed increased GDM risk mainly in those with higher BMI (G4 and G5 categories).
  • The findings indicate that understanding the relationship between PCOS and BMI can help tailor preconception counseling for women at risk for GDM.
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Introduction: Fournier's gangrene refers to a necrotizing fasciitis that mainly affects the perineal region and a condition that requires immediate debridement. This case involved elective debridement of Fournier's gangrene after the general condition was improved through antibiotic treatment instead of requesting an emergency debridement.

Case Presentation: The patient was an 85-year-old man with a performance status of 4 admitted to a nursing home.

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