Ginkgolide B Regulates CDDP Chemoresistance in Oral Cancer via the Platelet-Activating Factor Receptor Pathway.

The platelet-activating factor receptor (PAFR) is a key molecule that participates in intracellular signaling pathways, including regulating the activation of kinases. It is involved in cancer progression, but the detailed mechanism of its chemosensitivity is unknown. The purpose of the current study was to elucidate the mechanism regulating cisplatin (CDDP) sensitivity through PAFR functions in oral squamous cell carcinoma (OSCC).

Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer.

Circular RNAs (circRNAs), which form as covalently closed loop structures, have several biological functions such as regulation of cellular behavior by adsorbing microRNAs. However, there is limited information of circRNAs in oral squamous cell carcinoma (OSCC). Here, we aimed to elucidate the roles of aberrantly expressed circRNAs in OSCC.

Extremely enhanced N lasing in a filamentary plasma grating in ambient air.

Cavity-free air lasing offers a promising route towards the realization of atmospheric lasers for various applications such as remote sensing and standoff spectroscopy; however, achieving efficient generation and control of air lasing in ambient air is still a challenge. Here we show the experimental realization of a giant lasing enhancement by three to four orders of magnitude in ambient air for the self-seeded 2+ lasing at 428 nm, assigned to the +(=0) and +(=1) emission, by modulating the spatiotemporal overlap of ultrashort near-infrared control-pump pulses in a filamentary plasma grating; meanwhile, the spontaneous emission from the same transition is only enhanced by three to four times. We find that this enhancement is sensitive to the relative polarization and interference time of the two pulses, and reveal that the formation of the plasma grating induces different population variations in the +(=0) and +(=1) levels, resulting in an enormous population inversion between the two levels, thereby a higher gain for the giant enhancement of 2+ lasing in ambient air.

Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression.

Exosomes are involved in a wide range of biological processes in human cells. Considerable evidence suggests that engineered exosomes (eExosomes) containing therapeutic agents can attenuate the oncogenic activity of human cancer cells. Despite its biomedical relevance, no information has been available for oral squamous cell carcinoma (OSCC), and therefore the development of specific OSCC-targeting eExosomes (octExosomes) is urgently needed.

Absolute carrier-envelope-phase dependences of single and double ionization of methanol in a near-IR few-cycle laser field.

We investigate the carrier-envelope phase (CEP) dependences of the single and double ionization processes of methanol (CHOH) in an intense near-IR few-cycle laser field (2.1 × 10 W/cm) by the asymmetry in the ejection direction of CH for the non-hydrogen migration channels and CH for the hydrogen migration channels created through the C-O bond breaking after the ionization. Based on the absolute CEP values at the laser-molecule interaction point, calibrated by the method using intense few-cycle circularly polarized laser pulses [Fukahori et al.

Giant Enhancement of Air Lasing by Complete Population Inversion in N_{2}^{+}.

A fine manipulation of population transfer among molecular quantum levels is a key technology for control of molecular processes. When a light field intensity is increased to the TW-PW cm^{-2} level, it becomes possible to transfer a population to specific excited levels through nonlinear light-molecule interaction, but it has been a challenge to control the extent of the population transfer. We deplete the population in the X^{2}Σ_{g}^{+}(v=0) state of N_{2}^{+} almost completely by focusing a dual-color (800 nm and 1.

Rotational, Vibrational, and Electronic Modulations in N_{2}^{+} Lasing at 391 nm: Evidence of Coherent B^{2}Σ_{u}^{+}-X^{2}Σ_{g}^{+}-A^{2}Π_{u} Coupling.

We investigate lasing of a N_{2} gas induced by intense few-cycle near-IR laser pulses. By the pump-probe measurements, we reveal that the intensity of the B^{2}Σ_{u}^{+}-X^{2}Σ_{g}^{+} lasing emission of N_{2}^{+} oscillates at high (0.3-0.

Significant Enhancement of N_{2}^{+} Lasing by Polarization-Modulated Ultrashort Laser Pulses.

We show that the intensity of self-seeded N_{2}^{+} lasing at 391 nm, assigned to the B^{2}Σ_{u}^{+}(v^{'}=0)→X^{2}Σ_{g}^{+}(v^{''}=0) emission, is enhanced by 2 orders of magnitude by modulating in time the polarization of an intense ultrashort near-IR (40 fs, 800 nm) laser pulse with which N_{2} is irradiated. We find that this dramatic enhancement of the 391 nm lasing is sensitive to the temporal variation of the polarization state within the laser pulse while the intensity of the spontaneous fluorescence emission at 391 nm is kept constant when the polarization state varies. We conclude that a postionization multiple-state coupling, through which the population can be transferred from the X^{2}Σ_{g}^{+} state of N_{2}^{+} to the first electronically excited A^{2}Π_{u} state, leads to the depletion of the population in the X^{2}Σ_{g}^{+} state, and consequently, to the population inversion between the X^{2}Σ_{g}^{+} state and the B^{2}Σ_{u}^{+} state.

Eicosapantaenoic acid treatment based on the EPA/AA ratio in patients with coronary artery disease: follow-up data from the Tochigi Ryomo EPA/AA Trial in Coronary Artery Disease (TREAT-CAD) study.

Eicosapentaenoic acid (EPA) administration has been reported to decrease the incidence of cardiovascular events, and the serum EPA/arachidonic acid (AA) ratio has been identified as a potential new risk marker for coronary artery disease (CAD). The present study aimed to investigate the value of EPA treatment based on the EPA/AA ratio at baseline. We retrospectively analyzed clinical outcome data from 149 CAD patients with a baseline EPA/AA ratio ≤ 0.

Strong-Field Fourier Transform Vibrational Spectroscopy of D_{2}^{+} Using Few-Cycle Near-Infrared Laser Pulses.

The photoionization of D_{2} and dissociation of the resultant D_{2}^{+} are monitored by pump-probe measurements using intense near-infrared few-cycle laser pulses. The yields of D_{2}^{+} and D^{+} recorded up to the pump-probe delay time of 527 ps exhibit oscillatory structures reflecting the motion of the created vibrational wave packet of D_{2}^{+}, and the Fourier transform of the data in time domain reveals the vibrational level separations with uncertainties of 0.0002-0.

Screening of primary aldosteronism by clinical features and daily laboratory tests: combination of urine pH, sex, and serum K.

Objective: To develop and validate a scoring system for selection of patients who should proceed to endocrinologic examinations of primary aldosteronism in newly diagnosed hypertensive patients.

Methods: A multivariate logistic regression analysis for primary aldosteronism was undertaken by use of seven possible primary aldosteronism markers, age less than 40 years, female sex, moderate-to-severe hypertension, hypokalemia, serum Na minus Cl at least 40 mmol/l, serum uric acid 237.92 μmol/l or less (4.

Effect of a novel calcium channel blocker on abnormal nocturnal blood pressure in hypertensive patients.

The authors examined the effect of cilnidipine, a unique L/N-type calcium channel blocker, on abnormal nocturnal blood pressure (BP) dipping in Japanese hypertensive patients in the real world. The Ambulatory Blood Pressure Control and Home Blood Pressure (Morning and Evening) Lowering by N-Channel Blocker Cilnidipine (ACHIEVE-ONE), a large-scale clinical study, was designed to evaluate the effects of cilnidipine in daily medical practice. Among the study, 24-hour ambulatory BP data were obtained from 615 patients and classified according to their nocturnal dipping status as extreme dippers, dippers, nondippers, or risers.

[Effectiveness of network meeting system following practical pharmacy training].

We established a network meeting system program and used it to review a prior pharmaceutical practice training session. Pharmacists at Tokai University Hachioji Hospital gave lectures about dispensing and other tasks performed by clinical pharmacists to third-year undergraduate students at Tokyo University of Pharmacy and Life Sciences. After the lectures, discussions were held using the network meeting system, after which a questionnaire was completed by the students.

[Subject making and evaluation method for objective structured clinical examination (OSCE) in pharmaceutical practice].

The aim of this study was to discuss subject selection and the evaluation method for an objective structured clinical examination (OSCE) in pharmaceutical sciences. We designed the OSCE to assess pharmaceutical students' clinical ability. In this trial, there are three stations (ST1 in circle: dispensing powdered medicine, ST2 in circle: patient reception, ST3 in circle: drug counseling), and 25 students and six instructors participated.