Genome-wide polygenic score to predict chronic kidney disease across ancestries.

Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized for ancestrally diverse populations. By combining APOL1 risk genotypes with genome-wide association studies (GWAS) of kidney function, we designed, optimized and validated a genome-wide polygenic score (GPS) for CKD.

Design: voice activated door opener.

A voice activated garage door opener was designed for a handicapped person to open a garage door without assistance. This design uses speech recognition of one word. The activating word that was chosen is "up".