Publications by authors named "Toru Hiura"
Article Synopsis
- Small cell lung cancer (SCLC) often spreads rapidly, but some patients with paraneoplastic syndrome remain in limited-stage disease (LD) due to immune responses against tumor-related antigens.
- A study analyzed T cells from 35 SCLC patients, finding that those in LD had more immune effector T cells (Teff) compared to those in extended-stage disease (ED).
- The findings suggest that a high ratio of Teff to regulatory T cells (Treg) in LD-SCLC patients may serve as a biomarker for different stages of the disease and highlight the need to enhance Teff cells, especially Th17, to prevent disease spread.
A 70-year-old man with polycystic kidney disease developed nephrotic syndrome, deteriorating to renal insufficiency. Histological examination revealed IgA nephropathy. With treatment of prednisolone, an angiotensin-converting enzyme inhibitor, and an angiotensin II receptor-blocker, his proteinuria markedly decreased and renal function was stabilized.
View Article and Find Full Text PDFThe peripheral tolerance mechanism prevents effective antitumor immunity, even though tumor cells possess recognizable tumor-associated Ags. Recently, it has been elucidated that regulatory T cells (Treg) play a critical role in maintaining not only self-tolerance, but also tolerance of tumor cells. However, because the Treg that maintain self-tolerance arise naturally in the thymus and are thought to be anergic in peripheral, it is still unclear where and when Treg for tumor cells are generated.
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