In vitro behavior of layer-by-layer deposited molecular oligoelectrolyte films on Ti-6Al-4V surfaces.

Layer-by-layer self-assembled films of molecular oligoelectrolytes were used to modify Ti-6Al-4V surfaces in order to test their ability as potential drug delivery system. With regard to medical application the in vitro behavior of the modified material was investigated. The Ti-6Al-4V (6% aluminium, 4% vanadium) material was treated in a layer-by-layer (LbL) process with 2, 4, 6 and 8 layers of molecular oligoelectrolytes 1 and 2 and thereby doped with a fluorescent reporter molecule 2.

Layer-by-layer deposition of molecular oligoelectrolytes-investigation of assembling and degradation behaviour.

The assembly and degradation behavior of oligoelectrolyte multilayer films (OEMs) self assembled by layer-by-layer deposition of positively and negatively charged oligoelectrolytes 1-6 was investigated. Next to colorless oligoelectrolytes we have employed representatives involving chromophores, in particular porphyrins. This allows for the systematic observation of both assembly and disassembly of the OEMs using optical spectroscopy, where chromophore containing building blocks serve as reporter electrolytes.