Publications by authors named "Toritse Orubu"
Article Synopsis
- Microarray patches (MAPs), or microneedle patches, offer a promising solution to improve vaccine delivery in low- and middle-income countries (LMICs) and enhance immunization programs.
- The World Health Organization and partners are exploring how MAPs can address challenges in vaccine distribution and promote equitable access in these regions.
- The report discusses technical, economic, and programmatic hurdles identified by global stakeholders and suggests future directions for developing vaccine-MAP products.
Modified vaccinia virus Ankara (MVA)-vectored vaccines against malaria, influenza, tuberculosis and recently Ebola virus are in clinical development. Although this vector is safe and immunogenic in humans, efforts remain on-going to enhance immunogenicity through various approaches such as using stronger promoters to boost transgene expression. We previously reported that endogenous MVA promoters such as pB8 and pF11 increased transgene expression and immunogenicity, as compared to the conventional p7.
View Article and Find Full Text PDFCD8(+) T cell responses to vaccinia virus are directed almost exclusively against early gene products. The attenuated strain modified vaccinia virus Ankara (MVA) is under evaluation in clinical trials of new vaccines designed to elicit cellular immune responses against pathogens including Plasmodium spp., M.
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