Comparison of the osteoinductivity of bioimplants containing recombinant human bone morphogenetic proteins 2 (Infuse) and 7 (OP-1).

Objectives: Recent research has focused on application of growth factors such as bone morphogenetic proteins (BMPs) as alternatives to autogenous bone grafting. Two bone graft substitute bioimplants containing recombinant human BMPs (rhBMPs), Infuse (rhBMP-2) and OP-1 (rhBMP-7), are approved for human application but have never been compared side by side. The aim of this study was to provide a direct comparison of the osteoinductive activity of the 2 commercially available and approved rhBMP-containing bioimplants in their clinically available forms.

Juvenile idiopathic arthritis: a chronic pediatric musculoskeletal condition with significant orofacial manifestations.

Juvenile idiopathic arthritis (JIA), a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, begins before 16 years of age. The hallmark feature of JIA is chronic inflammation of the joints, but the term encompasses several disease categories. The cause of JIA is still poorly understood and none of the available drugs for JIA can cure the disease.

Fat embolism following posterior iliac graft harvest for jaw reconstruction: managing the complications of major surgery.

Oral and maxillofacial surgeons offer their patients a wide variety of surgical options that may be classified as major or minor surgery. Complications are part of surgery, but major surgery may lead to life-threatening complications that must be managed by the surgical team. Obtaining iliac graft tissue during oral and maxillofacial reconstruction carries the risk of rare but serious complications, such as deep vein thrombosis and fat embolism syndrome.