Publications by authors named "Toril Andersen"
Article Synopsis
- Vaginal infections often recur because they're caused by multiple pathogens, particularly bacteria and fungi, and current treatments may not be effective.
- A new treatment using chitosan, a mucoadhesive polymer with antifungal properties, is being developed in the form of chitosan-containing liposomes (chitosomes) to deliver antifungal and antibacterial drugs more efficiently.
- Research results show that these chitosomes are effective in prolonging drug release and inhibiting pathogen growth, suggesting they could significantly improve treatment outcomes for complex vaginal infections.
Mucoadhesive drug therapy destined for localized drug treatment is gaining increasing importance in today's drug development. Chitosan, due to its known biodegradability, bioadhesiveness and excellent safety profile offers means to improve mucosal drug therapy. We have used chitosan as mucoadhesive polymer to develop liposomes able to ensure prolonged residence time at vaginal site.
View Article and Find Full Text PDFMucoadhesive liposomes offer a potential for improved residence time of liposomal systems targeting contact with mucosal tissues, such as in buccal, oral, colon, and vaginal drug delivery. Most of the currently available methods rely on the coating of preformed liposomes by various mucoadhesive polymers. The aim of this study was to develop novel mucoadhesive system by the one-pot preparation method.
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