COVID-19 impairs oxygen delivery by altering red blood cell hematological, hemorheological, and oxygen transport properties.

Coronavirus disease 2019 (COVID-19) is characterized by impaired oxygen (O) homeostasis, including O sensing, uptake, transport/delivery, and consumption. Red blood cells (RBCs) are central to maintaining O homeostasis and undergo direct exposure to coronavirus . We thus hypothesized that COVID-19 alters RBC properties relevant to O homeostasis, including the hematological profile, Hb O transport characteristics, rheology, and the hypoxic vasodilatory (HVD) reflex.

Coagulation potential and the integrated omics of extracellular vesicles from COVID-19 positive patient plasma.

Extracellular vesicles (EVs) participate in cell-to-cell communication and contribute toward homeostasis under physiological conditions. But EVs can also contribute toward a wide array of pathophysiology like cancer, sepsis, sickle cell disease, and thrombotic disorders. COVID-19 infected patients are at an increased risk of aberrant coagulation, consistent with elevated circulating levels of ultra-high molecular weight VWF multimers, D-dimer and procoagulant EVs.