[Regularities of endogenous lipid metabolites formation in phorbol 12-miristate 13-acetate-stimulated peripheral blood lymphocytes at leukemia].

Regularities of biologically active lipid metabolites formation in dynamics (5, 10, 30, 60 s) by phorbol 12-miristate 13-acetate stimulation in [14C]palmitic acid have been investigated in normal and leukemia peripheral blood lymphocytes prelabeled with [14C]palmitate. In normal cells there was two-phase formation of 1,2-diacylglycerol (5, 30 s), lysophosphatidylcholine (10, 60 s), as well as free palmitic acid at 10 s of stimulation. Under the identical experimental conditions there was inhibition of investigated lipid release processes at early (5 and 10 s) stages of stimulation of leukemic lymphocytes.

[A comparative study of anapriline and carvedilol effectiveness in patients with thyrotoxicosis in pre- and postoperative periods].

Thyrotoxicosis often affects cardiovascular system. Structural-functional condition of the myocardium is essential in the outcome of surgical intervention on the thyroid in thyrotoxicosis and indicates effectiveness of the treatment. A comparative trial studied the effects of beta-blockers (anaprilin and carvedilol) on preoperative condition of left-ventricular (LV) myocardium and late after subtotal resection of the thyroid gland.