Publications by authors named "Torben W van Voorst"
Article Synopsis
- Tomosyns, traditionally thought to inhibit membrane fusion by competing with synaptobrevin-2/VAMP2, actually enhance synaptic vesicle fusion in their absence, leading to stronger synapses.
- A novel mouse model showed that tomosyn-1/2 deficiency results in faster synaptic depression and slower recovery, suggesting an unexpected role in regulating synaptic strength.
- The study indicates that tomosyns bind to synaptobrevin-2/VAMP2 complexes to prevent SNAP-25 association, thus modulating synaptic transmission rather than simply blocking fusion.
Dravet syndrome is a severe epileptic encephalopathy, characterized by (febrile) seizures, behavioural problems and developmental delay. Eighty per cent of patients with Dravet syndrome have a mutation in SCN1A, encoding Nav1.1.
View Article and Find Full Text PDFPharmacological options for neurodevelopmental disorders are limited to symptom suppressing agents that do not target underlying pathophysiological mechanisms. Studies on specific genetic disorders causing neurodevelopmental disorders have elucidated pathophysiological mechanisms to develop more rational treatments. Here, we present our concerted multi-level strategy 'BRAINMODEL', focusing on excitation/inhibition ratio homeostasis across different levels of neuroscientific interrogation.
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