Publications by authors named "Toral Vaishnani"
Article Synopsis
- - Chronic myeloid leukemia (CML) is a type of cancer characterized by the excessive growth of certain white blood cells, primarily driven by the presence of the Philadelphia (Ph) chromosome in over 90% of cases.
- - In a study of a 77-year-old man with CML, researchers discovered a novel genetic rearrangement involving three chromosomes (9, 22, and 5) that creates a specific fusion gene linked to the disease.
- - The findings underscore the importance of using advanced genetic testing methods, as they revealed complex chromosomal abnormalities that conventional cytogenetics might miss, enhancing our understanding of CML's genetic landscape.
The efficacy and treatment outcome of a CML patient are heavily dependent on BCR::ABL1 kinase domain (KD) mutation status. Next-generation sequencing technology is a bright alternative to the previously used sanger sequencing method due to its global presence in diagnostic setups, massive parallel sequencing ability, and far better sensitivity. In the present study, we have demonstrated a new protocol for kinase domain mutation analysis using the next-generation sequencing (NGS) method using the ion torrent sequencing platform.
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