Dement Geriatr Cogn Dis Extra
January 2019
Background: Few studies have assessed smoking and obesity together as risk factors for frontotemporal dementia (FTD) and Alzheimer's disease (AD).
Objective: To study smoking and obesity as risk factors for FTD and AD.
Methods: Ninety patients with FTD and 654 patients with AD were compared with 116 cognitively healthy elderly individuals in a longitudinal design with 15-31 years between measurements of risk factors before the dementia diagnosis.
Dement Geriatr Cogn Dis Extra
November 2018
Background: The roles of both anxiety and depression as risk factors for frontotemporal dementia (FTD) and Alzheimer's disease (AD) have not been previously investigated together.
Objective: To study anxiety and depression as independent risk factors for FTD and AD.
Methods: Eighty-four patients with FTD and 556 patients with AD were compared with 117 cognitively healthy (CH), elderly individuals.
Bakgrunn: Risikofaktorer for frontotemporal demens er lite kartlagt. Formålet med denne artikkelen var å gi en oppdatert oversikt over modifiserbare risikofaktorer for frontotemporal demens og vurdere kunnskapsgrunnlaget for kliniske anbefalinger for å redusere risiko for sykdommen.
Kunnskapsgrunnlag: Det ble utført søk i basene PsychInfo, Embase, PubMed og Cochrane i perioden mai 2016-april 2017.
Today, frontotemporal dementia (FTD) remains one of the most common forms of early-onset dementia, that is, before the age of 65, thus posing several diagnostic challenges to clinicians since symptoms are often mistaken for psychiatric or neurological diseases causing a delay in correct diagnosis, and the majority of patients with FTD present with symptoms at ages between 50 and 60. Genetic components are established risk factors for FTD, but the influence of lifestyle, comorbidity, and environmental factors on the risk of FTD is still unclear. Approximately 40% of individuals with FTD have a family history of dementia but less than 10% have a clear autosomal dominant pattern of inheritance.
View Article and Find Full Text PDFObjectives: To investigate the association between random measured glucose levels in middle and old age and dementia-related death.
Design: Population-based cohort study.
Setting: Norwegian Counties Study (middle-aged individuals; 35-49) and Cohort of Norway participants (older individuals; 65-80).
Background/aims: Our aims were two-fold: firstly, to investigate the association and interaction between apolipoprotein E (ApoE), lifestyle risk factors and dementia-related mortality and, secondly, to examine if using dementia-related mortality yielded comparable risk estimates for the ApoE genotypes as reported in studies using a clinical dementia diagnosis as the end point.
Methods: We used a nested case-control study with 561 cases drawn from dementia deaths in the Cohort of Norway (CONOR) and 584 alive controls.
Results: ApoE ε4 carriers were at increased risk of dementia-related mortality compared to noncarriers [odds ratio (OR) 2.
Objective: It is not fully understood how subjective feelings of psychological distress prognosticate dementia. Our aim was to investigate the association between self-reported psychological distress and risk of dementia-related mortality.
Method: We included 31,043 eligible individuals between the ages of 60 and 80 years, at time of examination, from the CONOR (Cohort of Norway) database.
Background: Findings from the literature vary in relation to whether physical activity brings about less cognitive decline in old age. The present study investigated self-reported levels of physical activity in old age and its association with the risk of dementia-related mortality.
Methods: We included data from 31,086 subjects, between 65 and 80 years old, from the CONOR (Cohort of Norway) database.
Background: It is estimated that 1,200 people under the age of 65 have been diagnosed with dementia in Norway. This article provides an overview of the types of dementia frequently seen in younger patients.
Material And Methods: The article is based on a non-systematic search in PubMed, as well as the authors' own clinical and research experience.
Aging Ment Health
April 2011
Objective: To investigate the quality of life (QoL) and depression and its correlates in carers living with early onset dementia (EOD) patients.
Method: The subjects were 49 carers, either married to or cohabiting with EOD patients, 38 with Alzheimer's disease and 11 with other types of dementia. The Quality of Life - Alzheimer Disease scale (QoL-AD) and Geriatric Depression Scale-15 items (GDS-15) were used.