Family history of thyroid disease and risk of congenital hypothyroidism in neonates with Down síndrome.

Introduction: Family history of thyroid disease (FHTD) constitutes a possible risk factor for congenital hypothyroidism (CH) in the general population; however, FHTD possible relationship with CH in subjects with Down syndrome (DS) has not yet been explored.

Objective: To determine whether FHTD is associated with an increased incidence of CH in neonates with DS.

Method: Hospital-based case-control study in 220 neonates with DS.