Publications by authors named "Toon Santermans"

Loss of gene function is common throughout evolution, even though it often leads to reduced fitness. In this study, we systematically evaluated how an organism adapts after deleting genes that are important for growth under oxidative stress. By evolving, sequencing, and phenotyping over 200 yeast lineages, we found that gene loss can enhance an organism's capacity to evolve and adapt.

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Mutations in the gene impair mitochondrial ubiquinone biosynthesis and extend lifespan in . We demonstrate here that this life extension is linked to the repression of cytoplasmic mRNA translation, independent of the alleged nuclear form of CLK-1. mutations inhibit polyribosome formation similarly to mutations that dampen insulin signaling.

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