Changes in adipokine levels and metabolic profiles following bariatric surgery.

Background: Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients. Abdominal obesity is frequently accompanied by metabolic syndrome (MS). Adipokines are cell signaling proteins that have direct impact upon the metabolic homeostasis.

GastroPanel® Biomarker Assay: The Most Comprehensive Test for Infection and Its Clinical Sequelae. A Critical Review.

Background/aim: Several clinical conditions seriously hamper the diagnostic accuracy of the commonly used tests for Helicobacter pylori (Hp), C-urea breath test (UBT) and stool antigen test (SAT). The present communication is a critical review of the potential limitations of UBT and SAT, and describes the approach on how these can be avoided. Drawbacks of the Hp tests: False-negative results are most often due to low bacterial load in the stomach due to: i) use of proton pump inhibitor medication; ii) use of antibiotics; iii) presence of atrophic gastritis and hypoacid stomach; iv); bleeding peptic ulcer; v) gastric cancer (GC) and vi) mucosal-associated lymphatic tissue lymphoma.

Serological biomarker testing helps avoiding unnecessary endoscopies in obese patients before bariatric surgery.

Background: To assess the value of serological biomarker testing as a substitute for esophagogastroduodenoscopy (EGDS) in pre-operative assessment of patients referred for bariatric surgery.

Methods: Sixty-five obese patients with a mean age of 43 years (range: 21-65) and a mean body mass index (BMI) of 44 (range: 36-59) were studied. The patients were tested with a four-biomarker panel: pepsinogen I and II, gastrin-17 (basal and stimulated), and (HP) antibodies (GastroPanel®, Biohit Oyj, Finland).

The Prevalence of Helicobacter pylori in Estonian Bariatric Surgery Patients.

() is one of the most important human pathogens that can cause duodenal and gastric ulcers, gastritis and stomach cancer. infection is considered to be a cause of limiting access to bariatric surgery. The aim of this study was to determine the prevalence of in patients with obesity going into bariatric surgery and to reveal the relationship between and clinical data.

Plasma levels of gastric biomarkers in patients after bariatric surgery: biomarkers after bariatric surgery.

Background/aims: To investigate the profile of stomach specific biomarkers in blood plasma after bariatric surgery.

Methodology: The study included 20 laparoscopic gastric bypass (LGBP) and 20 laparoscopic gastric sleeve (LGS) patients operated on average 22 months earlier. The biomarkers were fasting plasma level of pepsinogen I (PGI), pepsinogen II (PGII), PGI/PGII ratio, fasting and stimulated levels of amidated gastrin-17 (G17), and Helicobacter pylori antibodies (IgG).

Persistence of Helicobacter pylori infection in patients with peptic ulcer perforation.

Objective: In patients with perforated peptic ulcer (PPU) the convergence between the high eradication rate of Helicobacter pylori infection and low rates of ulcer relapse after treatment has been associated with reinfection by non-virulent strains. The objective of this study was to evaluate the persistence of infection by virulent H. pylori strains and ulcer recurrence in 33 patients with PPU one year after surgery and antimicrobial treatment.

Association of cagA and vacA genotypes of Helicobacter pylori with gastric diseases in Estonia.

Gastric biopsy specimens from 156 adult patients from southern Estonia suffering from chronic gastritis, peptic ulcer disease, and perforated peptic ulcer were analyzed by PCR. The cagA gene was evenly distributed throughout 87% of the specimens from the patients with the different gastric diseases. The presence of the cagA gene correlated with that of vacA signal sequence type s1a (99%).