Publications by authors named "Tony Qu"
Genetic engineering techniques have contributed to the now widespread use of zebrafish to investigate gene function, but zebrafish-based human disease studies, and particularly for neurological disorders, are limited. Here we used CRISPR-Cas9 to generate 40 single-gene mutant zebrafish lines representing catastrophic childhood epilepsies. We evaluated larval phenotypes using electrophysiological, behavioral, neuro-anatomical, survival and pharmacological assays.
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- Experience shapes behavior, but the brain mechanisms behind this are not fully understood, particularly in how network-level changes enhance performance.* -
- Researchers studied larval zebrafish to see how experience with live prey versus inert food affects their ability to successfully capture prey, finding that prior experience increases capture success by enhancing initiation of the attack.* -
- The study revealed that experienced zebrafish show heightened activity in specific brain areas (like the telencephalon and habenula) which helps them respond more quickly to visual stimuli, improving their overall prey capture performance.*