Publications by authors named "Tony Hong"

One attractive quality of zebrafish as a model organism for biological research is that transparency at early developmental stages allows the optical imaging of cellular and molecular events. However, this advantage cannot be applied to adult zebrafish. In this study, we explored the use of contrast-enhanced X-ray micro-computed tomography (microCT) on adult zebrafish in which the organism was stained with iodine, a simple and economical contrasting agent, after fixation.

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Objectives: The purpose of this study was to characterize clopidogrel hypersensitivity and describe its successful management with oral steroids without clopidogrel discontinuation.

Background: Hypersensitivity reactions to clopidogrel are poorly understood and present difficulty in management.

Methods: Patients diagnosed with clopidogrel hypersensitivity after percutaneous coronary intervention underwent evaluation and received oral prednisone without clopidogrel discontinuation.

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Background: Transradial percutaneous coronary intervention (TR-PCI) improves clinical outcomes compared to the transfemoral (TF) approach. However, inadequate training and experience has limited widespread adoption by interventional cardiologists.

Methods And Results: Clinical and procedural characteristics for TR-PCI were prospectively collected from 1999 to 2008.

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Background: Currently approved vascular closure devices (VCDs) are not recommended for use in arterial puncture sites distal to the common femoral artery (CFA) bifurcation. The StarClose™ vascular system (SC) is a unique VCD that does not contain intravascular components, a feature that may allow safe use in smaller vessels.

Objective: We sought to determine the efficacy and long-term safety of the SC for hemostasis of arterial punctures distal to the CFA bifurcation.

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Background: Adjunctive administration of the glycoprotein IIb/IIIa platelet receptor antagonist (GPA), abciximab, improves outcomes in patients undergoing rescue percutaneous coronary intervention (PCI). However, it is unknown if other GPAs provide a similar benefit in this setting.

Objective: We sought to compare angiographic and clinical outcomes of patients receiving abciximab or eptifibatide as an adjunct to rescue PCI.

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Objectives: The study aimed to determine the mechanism and predictors of procedural failure in patients undergoing percutaneous coronary intervention (PCI) from the transradial approach (TR).

Background: Transradial approach PCI reduces vascular complications compared with a transfemoral approach (TF). However, the mechanism and predictors of TR-PCI failure have not been well-characterized.

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Once highly selective protein A affinity is chosen for robust mAb downstream processing, the major role of polishing steps is to remove product related impurities, trace amounts of host cell proteins, DNA/RNA, and potential viral contaminants. Disposable systems can act as powerful options either to replace or in addition to polishing column chromatography to ensure product purity and excellent viral clearance power for patients' safety. In this presentation, the implementation of three disposable systems such as depth filtration, membrane chromatography, and nanometer filtration technology in a commercial process are introduced.

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Intraluminal filling defects are occasionally encountered on coronary angiography and often related with coronary thrombi. However, other conditions affecting the coronary arteries may present with similar angiographic findings causing diagnostic uncertainty. Accurate characterization of the angiographic filling defect is critical, particularly in patients planned for a percutaneous coronary intervention (PCI), as diagnosis of a coronary thrombus not only increases the risk of post procedural adverse events but also requires a specific therapeutic approach.

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Percutaneous coronary intervention (PCI) of coronary non-aorto ostial lesions offers technical challenges not encountered with other lesion sub types. Stenting of these lesions improves acute angiographic result and lowers the rate of restenosis. However, precise stent placement at non-aorto ostial lesions is technically difficult with risk of incomplete lesion coverage or jailing of the main branch.

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Background: The safety and efficacy of a radial approach for percutaneous coronary intervention (PCI) in octogenarians is not well established.

Methods: To evaluate the benefits of a radial approach for preventing vascular complications after PCI, clinical, procedural, and outcome data were prospectively collected and compared for 228 octogenarians undergoing elective PCI either through a radial or a femoral approach.

Results: Radial approach was associated with longer cannulation (3.

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Process-scale antibody production requires polishing steps with extremely high product throughput and robust operation. In this communication, the Sartobind Q membrane adsorber for process-scale antibody production is evaluated as an alternative to Q column chromatography. Although the capacity seen with large-scale membrane adsorbers is competitive with column chromatography, the same throughput is not achieved with the current scale-down models.

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Percutaneous coronary intervention for the treatment of aorto-ostial in-stent restenosis poses unique technical challenges not offered by other lesion subtypes. These difficulties are further enhanced when encountered with a case of deformed stent struts preventing coaxial guiding catheter engagement and introduction of guidewire through the true stent lumen. In this report, we describe a method of stenting through stent struts side-strut stenting for treating aorto-ostial in-stent restenosis associated with deformed stent struts resulting in good long-term outcome.

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Objectives: The aim of this study was to delineate the temporal profile of adventitial microvessel (Ad-MV) formation after stenting, its relationship to arterial wall hypoxia, and the effects of a tyrosine kinase inhibitor (TKI), SU11218, on Ad-MV and in-stent intimal hyperplasia (IH).

Background: Adventitial microvessels have been reported after arterial injury; however, the underlying stimulus for this response and its relationship to IH is unknown.

Methods: Coronary stenting was performed in 40 pigs randomized to SU11218 (n = 20) or placebo (n = 20).

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