Inferring the mobility of a middle Upper Paleolithic female skeleton from Caviglione (Liguria, Italy): Impact of trauma and mountainous terrain.

Mobility and territory occupation, the participation of injured individuals in group activities, and the role of women in early human groups are crucial issues in human evolution. Previously, a biomechanical study showed evidence of several traumas to the upper limb of the well-preserved middle Upper Paleolithic (UP) female skeleton from Caviglione (Caviglione 1, Liguria, Italy) but did not characterize their impact on locomotor behavior. Furthermore, mobility in the European UP context is thoroughly documented in males but not in females.

Early ontogeny of humeral trabecular bone in Neandertals and recent modern humans.

Trabecular bone ontogeny is well known in modern humans and unknown in Neandertals. Yet the bone developmental pattern is useful for interpreting fossils from evolutionary and functional perspectives. Interestingly, microstructure in early ontogeny is supposedly not influenced by high and specific mechanical loading related to the lifestyle of a human group and consequently does not directly depend on the activities of hunter-gatherers.

Age-related site-specific modifications in diaphyseal structural properties of the human fibula: Furrows and cross-sectional geometry.

Objectives: Fibular structure is related to locomotor behavior, which allows an exploration of mobility in past human populations with diaphyseal cross-sectional geometry (CSG). However, bone structure depends on age-related changes. Nonmechanical alterations can affect biomechanical investigations.

Neandertal features of the deciduous and permanent teeth from Portel-Ouest Cave (Ariège, France).

Objectives: We describe 14 unpublished and nine published teeth from the Mousterian level of Portel-Ouest (Ariège, France), dated to 44 ka. In a comparative context, we explore the taxonomical affinities of those teeth with Neandertals and modern humans which are both known to exist at that time. We further make some paleobiological inferences about this human group.

Trauma in the upper limb of an Upper Paleolithic female from Caviglione cave (Liguria, Italy): Etiology and after-effects in bone biomechanical properties.

The impact of injury on the health and activities of human foragers is of great interest for understanding the adaptability of past populations to their environments. For the Gravettian female of Caviglione 1, a violent blow has been suggested as the origin of the left radial fracture, and abnormal body asymmetry has been observed. Access to high resolution CT-scans of the upper limb allows us to address new etiologic considerations and assess the after-effects of trauma on bone biomechanical properties by focusing on cortical and trabecular bones and conducting a comparative analysis of cross-sectional geometric properties in an Upper Paleolithic context.

Body mass prediction from femoral volume and sixteen other femoral variables in the elderly: BMI and adipose tissue effects.

Objectives: The frequently used prediction equations of body mass do not seem appropriate for elderly individuals. Here, we establish the relationship between femoral dimensions and known body mass in elderly individuals in order to develop prediction formulas and identify the factors affecting their accuracy.

Materials And Methods: The body mass linear least-squares regression is based on 17 femoral dimensions, including femoral volume, and 66 individuals.

The accuracy of body mass prediction for elderly specimens: Implications for paleoanthropology and legal medicine.

Different practices in paleoanthropology and legal medicine raise questions concerning the robustness of body mass (BM) prediction. Integrating personal identification from body mass estimation with skeleton is not a classic approach in legal medicine. The originality of our study is the use of an elderly sample in order to push prediction methods to their limits and to discuss about implications in paleoanthropology and legal medicine.

The endostructural pattern of a middle pleistocene human femoral diaphysis from the Karain E site (Southern Anatolia, Turkey).

Objective: The human femur from Karain E Cave (Turkey) exhumed from a Mousterian level provided the opportunity to make an incursion into the structural morphology of a late adolescent, or a young adult, femoral shaft from the late Middle Pleistocene of Anatolia.

Methods: Considering the chrono-ecogeographical context, this study focuses particularly on the endostructural morphological similarities between Karain and Neanderthal fossils.

Results: Comparative analysis shows that some femoral features of the Karain specimen are frequently observed in Neanderthals, in comparison to some Middle Pleistocene Homo and Middle/Upper Paleolithic modern humans.

Characterization of the GATC regulatory network in E. coli.

Background: The tetranucleotide GATC is methylated in Escherichia. coli by the DNA methyltransferase (Dam) and is known to be implicated in numerous cellular processes. Mutants lacking Dam are characterized by a pleiotropic phenotype.

The difficult interpretation of transcriptome data: the case of the GATC regulatory network.

Genomic analyses on part of Escherichia coli's chromosome had suggested the existence of a GATC regulated network. This has recently been confirmed through a transcriptome analysis. Two hypotheses about the molecular control mechanism have been proposed-(i) the GATC network regulation is caused by the presence of GATC clusters within the coding sequences; the regulation is the direct consequence of the clusters' hemi-methylation and therefore their elevated melting temperature, (ii) the regulation is caused by the presence of GATCs in the non-coding 500 bp upstream regions of the affected genes; it is the consequence of an interaction with a regulatory protein like Fnr or CAP.