Publications by authors named "Toni Ingolf Gossmann"
Objective: The composition of the healthy human adult gut microbiome is relatively stable over prolonged periods, and representatives of the most highly abundant and prevalent species have been cultured and described. However, microbial abundances can change on perturbations, such as antibiotics intake, enabling the identification and characterisation of otherwise low abundant species.
Design: Analysing gut microbial time-series data, we used shotgun metagenomics to create strain level taxonomic and functional profiles.
Article Synopsis
- Molecular phylogenomics uses genomic data to study evolutionary relationships, but changes in protein interactions can lead to functional diversification.
- To explore this, the study combines phylogenomics with interaction proteomics, focusing on the shelterin complex that protects telomeres across 16 vertebrate species, spanning 450 million years.
- The findings identify new telomere-associated proteins and illustrate how proteins like TERF1 evolved to perform specific functions in different lineages, demonstrating that phylointeractomics can provide insights into protein function evolution and support phylogenomic relationships.