Publications by authors named "Toni E"
Article Synopsis
- XR technologies like virtual, augmented, and mixed reality show great promise in enhancing surgical training by overcoming the limitations of traditional methods.
- An umbrella review conducted in 2024 analyzed 44 studies focusing on the acceptance and effectiveness of XR in surgical training, revealing improved skills and accuracy while reducing risks and operating time.
- Key factors influencing XR adoption include user-friendly systems, positive feedback from experienced surgeons, and the need for better resources to address financial and technical challenges.
The symbiotic system Azolla filiculoides-Trichormus azollae was exposed for ten days to environmentally relevant concentrations (i.e. 0.
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- Checkpoint inhibitor-induced steroid-refractory (sr) and steroid-dependent (sd) immune-related adverse events (irAE) affect around 11% of patients, resulting in worse outcomes and no established second-line treatments from prospective trials.* -
- A study compared the efficacy of extracorporeal photopheresis (ECP) with second-line immunosuppressants (SLI) in 21 patients suffering from sr/sd-irAE, showing ECP had a higher clinical response (93% vs. 80%) and better quality of life scores.* -
- Results indicated that ECP patients experienced longer overall survival (23 months vs. 12 months) and lower cancer progression rates, suggesting ECP as a
. Children's vulnerability to drug-related side effects has been highlighted in several studies. However, there is no consensus on the risk factors associated with these side effects.
View Article and Find Full Text PDFBackground: Recently, the use of telemedicine technology has increased due to the Covid-19 pandemic. Cardiovascular diseases management is one of the areas that has benefited from using this technology. This study aimed to identify the applications of telemedicine for cardiovascular diseases management during the Covid-19 pandemic.
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- VR technology has been increasingly utilized to support cancer patients by addressing their physical, emotional, and functional needs, as highlighted in a systematic review conducted in 2024.
- The review analyzed 33 studies, finding that VR interventions significantly reduced anxiety, pain, and fatigue while enhancing mood and overall quality of life, with high satisfaction rates from both patients and healthcare providers.
- Despite some technical limitations in visual performance and realism, the promising benefits of VR suggest a need for further research to improve its applications in cancer supportive care.
Background: Despite the recent advances in cancer treatment, the therapeutic options for patients with biliary tract cancer are still very limited and the prognosis very poor. More than 50% of newly diagnosed patients with biliary tract cancer are not amenable to curative surgical treatment and thus treated with palliative systemic treatment. Malignant bile duct obstructions in patients with perihilar and/or ductal cholangiocarcinoma (CCA) represents one of the most important challenges in the management of these patients, owning to the risk represented by developing life-threatening cholangitis which, in turn, limits the use of systemic treatment.
View Article and Find Full Text PDFBackground: Congenital heart disease (CHD) is one of the leading causes of death. Safe and timely medical interventions, especially in children, can prolong their survival. The drugs prescribed for children with CHD are mainly based on the outcomes of drug therapy in adults with cardiovascular diseases, and their adverse drug reactions (ADRs) might be different.
View Article and Find Full Text PDFBackground: Drug safety relies on advanced methods for timely and accurate prediction of side effects. To tackle this requirement, this scoping review examines machine-learning approaches for predicting drug-related side effects with a particular focus on chemical, biological, and phenotypical features.
Methods: This was a scoping review in which a comprehensive search was conducted in various databases from 1 January 2013 to 31 December 2023.
Purpose: In the phase III HIMALAYA study (ClinicalTrials.gov identifier: NCT03298451) in unresectable hepatocellular carcinoma (uHCC), the Single Tremelimumab Regular Interval Durvalumab (STRIDE) regimen significantly improved overall survival versus sorafenib, and durvalumab monotherapy was noninferior to sorafenib. Patient-reported outcomes (PROs), a secondary outcome from HIMALAYA, are reported here.
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- A study evaluated the efficacy and safety of first-line therapies for hepatocellular carcinoma (HCC), specifically comparing atezolizumab/bevacizumab (atezo/bev) and lenvatinib, focusing on bleeding and thromboembolic events.
- A total of 464 patients from seven centers in Germany and Austria were analyzed, revealing that bleeding and thromboembolic events occurred in similar rates for both treatments within 6 months.
- The findings suggest that safety concerns regarding bleeding and thromboembolic events might not significantly influence clinical decisions when selecting between atezo/bev and lenvatinib for HCC treatment.*
An insight into the use of telemedicine technology for cancer patients during the Covid-19 pandemic: a scoping review.
BMC Med Inform Decis Mak
April 2024
Background: The use of telemedicine technology has significantly increased in recent years, particularly during the Covid-19 pandemic. This study aimed to investigate the use of telemedicine technology for cancer patients during the Covid-19 pandemic.
Methods: This was a scoping review conducted in 2023.
For decades, treatment of advanced biliary tract cancer (BTC) was confined to the use of chemotherapy. In recent years however, the number of therapeutic options available for patients with unresectable BTC have drastically increased, with immunotherapy and targeted treatment gradually joining the ranks of guideline-recommended treatment regimens. The aim of the present review is to summarise the current knowledge on unresectable BTC focusing on epidemiology, anatomical distribution and current strategies for systemic treatment.
View Article and Find Full Text PDFBackground: In the phase III HIMALAYA study (NCT03298451) in unresectable hepatocellular carcinoma (uHCC), STRIDE (Single Tremelimumab Regular Interval Durvalumab) significantly improved overall survival (OS) versus sorafenib; durvalumab monotherapy was noninferior to sorafenib for OS. Results reported herein are from a 4-year updated OS analysis of HIMALAYA.
Patients And Methods: Participants with uHCC and no previous systemic treatment were randomized to STRIDE (n = 393), durvalumab (n = 389), or sorafenib (n = 389).
Background: Combined hepatocellular-cholangiocarcinoma (cHCC-iCCA) is a rare type of primary liver cancer displaying characteristics of both hepatocytic and cholangiocytic differentiation.
Summary: Because of its aggressive nature, patients with cHCC-iCCA exhibit a poorer prognosis than those with HCC. Surgical resection and liver transplantation may be considered curative treatment approaches; however, only a minority of patients are eligible at the time of diagnosis, and postoperative recurrence rates are high.
Article Synopsis
- - The study created a new endoscopic scoring system for immune-mediated colitis (IMC) to help determine when to use selective immunosuppressive therapy (SIT) more effectively than relying solely on clinical symptoms.
- - Researchers analyzed data from 674 patients and identified ten key endoscopic features, resulting in an IMC endoscopic score (IMCES) that showed 82.8% specificity for SIT guidance with a score cutoff of 4.
- - The findings emphasized the importance of early endoscopy, showing that it helps in the timely application of SIT, making this the largest multicenter research to establish an effective scoring system for IMC management.
Purpose: To investigate the prognostic value of computed tomography (CT) derived imaging biomarkers in hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) and develop a predictive nomogram model.
Patients And Methods: This retrospective study included 178 patients with histopathologically confirmed HCC who underwent liver transplantation between 2007 and 2021 at the two academic liver centers. We evaluated dedicated imaging features from baseline multiphase contrast-enhanced CT supplemented by several clinical findings and laboratory parameters.