Publications by authors named "Tongzheng Chen"
Background: Temozolomide (TMZ) is used in the treatment of glioblastoma (GBM). However, the primary obstacle remains the emergence of TMZ chemotherapy resistance. NONO and SFPQ are multifunctional nuclear proteins involved in genome stability and gene regulation.
View Article and Find Full Text PDFBackground: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical application of immunotherapy, the precise roles and characteristics of immune cell subtypes, how glioma induces subtype transformation of immune cells and its impact on glioma progression have yet to be understood.
Aim Of The Review: In this review, we comprehensively center on the four major immune cells within the glioma microenvironment, particularly neutrophils, macrophages, lymphocytes, myeloid-derived suppressor cells (MDSCs), and other significant immune cells.
Article Synopsis
- * Research shows that reducing TAGLN2 levels can decrease GBM cell growth and invasion, increase cell death, and enhance sensitivity to TMZ, while increased TAGLN2 promotes TMZ resistance.
- * The study also reveals that TAGLN2 interacts with the ERK1/2 signaling pathway and is regulated by NF-κB, impacting the expression of the repair enzyme MGMT, suggesting potential avenues for targeted therapies to improve GBM treatment outcomes.