Targeting the Skin: The Study of a Bottlebrush Polymer-Antisense Oligonucleotide Conjugate in a Psoriasis Mouse Model.

The investigation of gene regulation therapeutics for the treatment of skin-related diseases is rarely explored in part due to inefficient systemic delivery. In this study, a bottlebrush polymer-antisense oligonucleotide (ASO) conjugate, termed pacDNA, designed to target IL-17 receptor A (IL-17RA), which is involved in psoriasis pathogenesis is presented. Systemic administration of pacDNA led to its accumulation in epidermis, dermis, and hypodermis of mouse skin, reduced IL-17RA gene expression in skin, and significantly reversed the development of imiquimod (IMQ)-induced psoriasis in a mouse model.

Inhalable Bottlebrush Polymer Bioconjugates as Vectors for Efficient Pulmonary Delivery of Oligonucleotides.

Antisense oligonucleotides hold therapeutic promise for various lung disorders, but their efficacy is limited by suboptimal delivery. To address this challenge, we explored the use of inhaled bottlebrush polymer-DNA conjugates, named pacDNA, as a delivery strategy. Inhaled pacDNA exhibits superior mucus penetration, achieving a uniform and sustained lung distribution in mice.

Plasma-Engineered N-CoO Nanowire Array as a Bifunctional Electrode for Supercapacitor and Electrocatalysis.

Surface engineering has achieved great success in enhancing the electrochemical activity of CoO. However, the previously reported methods always involve high-temperature calcination processes which are prone to induce agglomeration of the nanostructure, leading to the attenuation of performance. In this work, CoO nanowires were successfully modified by a low-temperature NH/Ar plasma treatment, which simultaneously generated a porous structure and efficient nitrogen doping with no agglomeration.