Publications by authors named "Tongmei Xiao"
Article Synopsis
- - PCSK9 is a protein that binds to LDLR in the liver and causes its degradation, leading to higher cholesterol levels; targeting PCSK9 can help manage cholesterol levels and reduce conditions like hypercholesterolemia and atherosclerosis.
- - A new compound called E28362 was identified as a potential PCSK9 inhibitor through virtual screening, showing promise in increasing LDLR levels and reducing LDL cholesterol in lab tests and animal models.
- - In studies with hamsters and mice on high-fat diets, E28362 effectively lowered cholesterol and triglyceride levels and decreased atherosclerotic lesions, indicating its potential as a treatment for cholesterol-related diseases.
Two previous unreported epipolythiodioxopiperazines of the emestrin family, namely, noremestrin A () and secoemestrin E (), were successfully isolated from the fungal source sp. 1454. Employing comprehensive spectroscopic techniques, such as high-resolution electrospray ionization mass spectrometry, infrared, and nuclear magnetic resonance (NMR), along with NMR and electronic circular dichroism calculations, the chemical structures of compounds and were elucidated.
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- Five isocoumarin derivatives were isolated from the culture extract of CPCC 400810, including three new compounds named aspermarolides A-C.
- The structures of the compounds were analyzed using spectroscopic techniques, with specific focus on determining double bond geometry and absolute configuration.
- None of the compounds demonstrated cytotoxic effects against the HepG2 and HeLa human cancer cell lines tested.
In this paper, we present the discovery of a novel salicylic acid derivative, moldavica acid A (), and a new natural dibenzo[b,f]oxepin, moldavica acid B (), together with four known phenylpropionic acids (-) and protocatechuic acid () that were isolated from L. Their structures were elucidated by comprehensive spectroscopic methods, including infrared and nuclear magnetic resonance. Compound is the first example of salicylic acid linking a carboxylated -pyrone via an ethyl bridge.
View Article and Find Full Text PDFPrenylemestrins A and B ( and , respectively), two unusual epipolythiodioxopiperazines featuring a thioethanothio bridge instead of a polysulfide bridge, were isolated from the fungus sp. CPCC 400858 guided by genomic analysis. Their structures were determined by extensive spectroscopic data, NMR and ECD calculations, and X-ray diffraction analysis.
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- Researchers isolated and identified a new compound called fusapyrone A from rice fermentation of a desert fungus (species CPCC 401218).
- The structure of fusapyrone A was determined using various analytical techniques, including mass spectrometry and nuclear magnetic resonance (NMR).
- The compound exhibited weak antiproliferative activity against Hela cells with an inhibitory concentration (IC) of 50.6 μM.