Nonlinear Relationship Between Coronary Perfusion Pressure and In-Hospital Outcomes After Infant Congenital Heart Surgery.

Objectives: Our goal was to evaluate the associations between postoperative coronary perfusion pressure (CPP) values and in-hospital outcomes in infants after congenital cardiac surgery. Our goal was to assess the relationship between postoperative coronary perfusion pressure (CPP) values and in-hospital outcomes in infants following congenital cardiac surgery.

Methods: In this study, we conducted a retrospective analysis on a cohort of 296 consecutive infant patients (aged 31-120 days) who underwent congenital cardiac surgery between 1 January 2019 and 30 April 2019.

Atypical deletion of Williams-Beuren syndrome reveals the mechanism of neurodevelopmental disorders.

Genes associated with specific neurocognitive phenotypes in Williams-Beuren syndrome are still controversially discussed. This study identified nine patients with atypical deletions out of 111 patients with Williams-Beuren syndrome; these deletions included seven smaller deletions and two larger deletions. One patient had normal neurodevelopment with a deletion of genes on the distal side of the Williams-Beuren syndrome chromosomal region, including GTF2I and GTF2IRD1.