Publications by authors named "Tongjun Song"
Background: Esophageal squamous cell carcinoma (ESCC) is a common malignant tumor of the digestive tract with a poor prognosis. The tumor microenvironment (TME) is mainly composed of tumor cells, stromal cells, and immune cells and plays an important role in ESCC development. There are substantial differences in tumor purity among different parts of ESCC tissues, consisting of distinct immune and stromal cells and variations in the status of hypoxia.
View Article and Find Full Text PDFBackground: The most frequent mode of progression in the majority of non-small cell lung cancer (NSCLC) patients treated with Epidermal growth factor - receptor tyrosine kinase inhibitors (EGFR-TKIs) is failure to respond to treatment at the primary lesion, suggesting that concurrent radiotherapy (CRT) to the primary lesion (CPRT) during first-line treatment with EGFR-TKI may be a novel therapeutic approach with a potential of additional benefit for metastatic NSCLC. Therefore, this study investigated the progression-free survival (PFS) and safety of CPRT during first-line icotinib treatment in NSCLC patients with EGFR mutations.
Methods: EGFR-mutant NSCLC patients diagnosed with limited multiple metastases were treated with first-line icotinib.
Article Synopsis
- * The review outlines three pathways of HSV latent infection, explores the role of specific types of RNA in regulating HSV, and discusses how modifying these pathways could aid in vaccine and oncolytic HSV development.
- * Findings suggest that deleting certain latency-associated transcripts (LAT) can decrease HSV latency and reactivation, indicating potential strategies for creating safer and more effective HSV therapies and emphasizing RNA interference as a promising area for future research.