Publications by authors named "Tonggen Liu"
Itaconate is a key anti-inflammatory/antibacterial metabolite in pathogen-macrophage interactions that induces adaptive changes in Pseudomonas aeruginosa-exposed airways. However, the impact and mechanisms underlying itaconate metabolism remain unclear. Our study reveals that itaconate significantly upregulates the expression of pyoverdine in P.
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- β--acetylhexosaminidases from the GH20 family are crucial enzymes for modifying oligosaccharides, with significant roles in biology and biotechnology.
- The study focused on Am2136, a specific β--acetylhexosaminidase from an anaerobic gut bacterium, demonstrating its ability to cleave mucin glycans and highlighting its generalist nature by hydrolyzing β-linkages of various substrates.
- The research also uncovered that the enzyme's activity is enhanced by nucleotides, suggesting a novel regulatory mechanism linked to structural interactions between enzyme domains, which could facilitate the development of targeted glycan-modifying catalysts.
Article Synopsis
- - Bacterial type II toxin-antitoxin (TA) systems are important genetic elements that help regulate various physiological processes by producing an antitoxin to neutralize a corresponding toxin.
- - Research focused on the antitoxin HigA showed that its absence led to increased expression of pathogenic proteins and influenced the expression of virulence-related secretion systems (T3SS and T6SS) by interacting with their promoter regions.
- - The study suggests that HigA plays a crucial role in bacterial infections, indicating that targeting the HigBA TA system could be a potential strategy for developing new antibacterial treatments.