Propensity-matched study on locally advanced esophageal cancer: surgery versus post-operative radiotherapy.

Background: This study aims to delineate the long-term outcomes and recurrence patterns of locally advanced thoracic esophageal squamous cell carcinoma (TESCC) patients managed with or without postoperative radiotherapy (PORT).

Methods: A retrospective cohort from two academic centers, encompassing patients who initially underwent esophagectomy and were pathologically staged T3-4, was analyzed. Survival outcomes were constructed using Kaplan-Meier method, with survival significance was evaluated using the log-rank test.

attenuates radiation-induced cardiac hypertrophy and apoptosis by degrading in cardiomyocytes.

Radiation-induced heart disease (RIHD) is a severe delayed complication of thoracic irradiation (IR). Endonuclease/exonuclease/phosphatase family domain-containing 1 ( ) plays an important role in DNA damage repair, but its role in RIHD is less known. In this study, global knockout mice, C57BL/6J mice, and C57BL/6J mice overexpressing are treated with radiation at a total dose of 20 Gy or 0 Gy.