Publications by authors named "Tong-yu Xu"
Article Synopsis
- Human chorionic gonadotropin (hCG) plays a key role in improving endometrial receptivity, which is crucial for embryo implantation, as demonstrated in a study using mouse models.
- The research focused on the miR-126-3p/PIK3R2/PI3K/Akt/eNOS signaling pathway, showing that hCG enhances this pathway, which involves increased expression of certain proteins and suppression of others.
- Results indicated that hCG treatment boosted cell proliferation in endometrial epithelial cells (EECs) while downregulating miR-126-3p, confirming that hCG helps to activate the PI3K/Akt/eNOS pathway to promote better implantation conditions.
Type 2 diabetes mellitus (T2DM) is accompanied by abnormal glucose metabolism and low-grade chronic inflammation. Fibroblast growth factor 21 (FGF-21) is a novel metabolic regulator and can function as an endocrine hormone to regulate glucose and lipid metabolism. Recently, FGF-21 was found to have anti-inflammatory effect, to our knowledge, the effect of FGF-21 on inflammatory state in diabetes has not been elucidated.
View Article and Find Full Text PDFThis study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on type 2 diabetic mice model and to provide mechanistic insights into its therapeutic effect. Type 2 diabetic animal model was established with high calorie fat diet and low dose streptozotocin (STZ) injection. Mice were then randomized into 5 groups: model control, FGF21 0.
View Article and Find Full Text PDFThis study is to evaluate the therapeutic effect of fibroblast growth factor 21 (FGF21) on hypertension induced by insulin resistance in rats and to provide mechanistic insights into its therapeutic effect. Male Sprague-Dawley (SD) rats were fed with high-fructose (10%) water to develop mild hypertensive models within 4 weeks, then randomized into 4 groups: model control, FGF21 0.25, 0.
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