Anti-angiogenic effect of total saponins of Rhizoma on collagen induced-arthritis in rats.

Rheumatoid arthritis (RA) is a common chronic autoimmune and incurable disease. The aim of the present study was to investigate the therapeutic effect and mechanism of the total saponins of Rhizoma (TSRDN) in RA. A collagen induced-arthritis (CIA) rat model was established.