LncRNA-MEG3/miR-93-5p/SMAD7 axis mediates proliferative and inflammatory phenotypes of fibroblast-like synoviocytes in rheumatoid arthritis.

Synovial hyperplasia, inflammation and immune cell infiltration are the central pathological basis of rheumatoid arthritis (RA). Nonetheless, the cellular, molecular and immunological mechanisms of RA remain poorly understood. An integrated analysis of single-cell RNA (scRNA) and bulk RNA sequencing datasets‌ aimed to unravel the cellular landscape, differentiation trajectory, transcriptome signature, and immunoinfiltration feature of RA synovium.

Identification of serum exosomal lncRNAs and their potential regulation of characteristic genes of fibroblast-like synoviocytes in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a common autoimmune disease whose pathogenesis is poorly understand. Gaps in laboratory biomarkers cause a lack of clinically available strategies for the early diagnosis and treatment of RA. This study aims to identify serum exosomal lncRNAs as promising biomarkers and to unravel potential mechanisms by which they affect characteristic genes of fibroblast-like synoviocytes (FLSs) to induce RA malignant properties.