Publications by authors named "Tong-Mei Yang"
Article Synopsis
- Atherosclerosis is a major contributor to cardiovascular disease, influenced by factors like inflammation, lipid imbalances, and oxidative stress.
- Peroxisome proliferator-activated receptors (PPARs) are crucial nuclear receptors that regulate genes related to lipid metabolism, inflammation, and cellular stress response, and have been thoroughly studied since the 1990s.
- Recent research from 2018 to now highlights how PPAR activation might reduce atherosclerosis by influencing lipid metabolism and inflammation, and discusses developments in PPAR modulators, providing insights for researchers, pharmacologists, and clinicians.
Macrophages are involved in the whole process of atherosclerosis, which is characterized by accumulation of lipid and inflammation. Presently, clinically used lipid-lowering drugs cannot completely retard the progress of atherosclerosis. Liver X receptor (LXR) plays a key role in regulation of lipid metabolism and inflammation.
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