Publications by authors named "Tong-Gen Liu"
Article Synopsis
- β--acetylhexosaminidases from the GH20 family are crucial enzymes for modifying oligosaccharides, with significant roles in biology and biotechnology.
- The study focused on Am2136, a specific β--acetylhexosaminidase from an anaerobic gut bacterium, demonstrating its ability to cleave mucin glycans and highlighting its generalist nature by hydrolyzing β-linkages of various substrates.
- The research also uncovered that the enzyme's activity is enhanced by nucleotides, suggesting a novel regulatory mechanism linked to structural interactions between enzyme domains, which could facilitate the development of targeted glycan-modifying catalysts.
Structural analysis of the sulfatase AmAS from Akkermansia muciniphila.
Acta Crystallogr D Struct Biol
December 2021
Article Synopsis
- Akkermansia muciniphila is a significant gut bacterium that helps modulate immune responses and provides nutrients for intestinal health.
- Research focused on the structure of its sulfatase enzyme, AmAS, revealing key areas that are critical for its function and substrate binding.
- Understanding the structural differences in these sulfatases could clarify their roles in breaking down complex sugars and their interactions within the human gut.