Improved bacterial cellulose production by Acetobacter oryzoeni MGC-N8819 in tobacco waste extract coupled with nicotine removal by Pseudomonas sp. JY-Q/5∆.

As the substrate, tobacco waste extract (TWE) can produce bacterial cellulose (BC), a biobased material. However, nicotine inhibits BC production (adding 0.8 g/L nicotine to the HS medium had a negative effect on BC synthesis) and needs to be removed.

Diagnostic performance of metagenomic next-generation sequencing among hematological malignancy patients with bloodstream infections after antimicrobial therapy.

Background: Metagenomic next-generation sequencing (mNGS) is an effective method for detecting pathogenic pathogens of bloodstream infection (BSI). However, there is no consensus on whether the use of antibiotics affects the diagnostic performance of mNGS. We conducted a prospective clinical study aiming to evaluate the effect of antimicrobial treatment on mNGS.

Association of α-klotho concentrations with cardiovascular and all-cause mortality in American adults with depression: a national prospective cohort study.

This study examines α-klotho levels in depressed American adults and their association with cardiovascular disease and all-cause mortality, utilizing data from the National Health and Nutrition Examination Survey (2007-2016) and mortality details from the National Death Index up to December 31, 2019. Including 3329 participants with depression, findings revealed 485 all-cause and 113 cardiovascular deaths. To investigate the nonlinear association between α-klotho and mortality, the Cox proportional hazards regression model, restricted cubic splines, and two-piecewise Cox proportional hazards model were developed.

Toripalimab plus chemotherapy for first line treatment of advanced non-small cell lung cancer (CHOICE-01): final OS and biomarker exploration of a randomized, double-blind, phase 3 trial.

A randomized double-blind phase 3 trial (CHOICE-01, NCT03856411) demonstrated that combining toripalimab with chemotherapy substantially improves progression-free survival (PFS) in advanced non-small cell lung cancer (NSCLC) patients without pretreatment. This study presents the prespecified final analysis of overall survival (OS) and biomarkers utilizing circulating tumor DNA (ctDNA) and tissue-based sequencing. Additionally, the analysis revealed a higher median overall survival (OS, 23.

Structural Feature of Salty/Saltiness-Enhancing Peptides Derived from and Their Stability during Subsequent Thermal Treatment and Maillard Reaction.

Through a quantitative analysis of saltiness perception, favorable enzymatic hydrolysis parameters were confirmed for the preparation of saltiness-enhancing peptide mixtures from . The enzymatic hydrolysate was fractionated into four fractions (F1-F4) by gel chromatography, with F3 exhibiting the strongest saltiness-enhancing effect (22% increase). LC-MS/MS analysis of F3 identified 36 peptides, and their secondary structures and interactions with the TMC4 receptor were examined through circular dichroism spectroscopy and molecular docking.

Search for meaning alleviated individual depressive symptoms during COVID-19 pandemic: The mediating role of optimism.

The COVID-19 pandemic and subsequent quarantine measures have disrupted people's normal pace of life and created excessive pressure. The current study examined the mitigating effect of search for meaning in life on individual depressive symptoms and the mediating role of optimism during COVID-19 lockdown period. A total of 462 participants (M = 37.

ReAlign-N: an integrated realignment approach for multiple nucleic acid sequence alignment, combining global and local realignments.

Ensuring accurate multiple sequence alignment (MSA) is essential for comprehensive biological sequence analysis. However, the complexity of evolutionary relationships often results in variations that generic alignment tools may not adequately address. Realignment is crucial to remedy this issue.

Characterization and clinical outcomes of outpatients with subacute or chronic post COVID-19 cough: a real-world study.

Background: Limited research exists on the features and management of post-COVID cough. This real-world study investigates outpatients with subacute or chronic post-COVID cough, aiming to delineate characteristics and regimen responses within the population.

Method: We enrolled eligible patients from our outpatient unit between August 2023 and February 2024.

Manipulating Trimetal Catalytic Activities for Efficient Urea Electrooxidation-Coupled Hydrogen Production at Ampere-Level Current Densities.

Replacing the oxygen evolution reaction (OER) with the urea oxidation reaction (UOR) in conjunction with the hydrogen evolution reaction (HER) offers a feasible and environmentally friendly approach for handling urea-rich wastewater and generating energy-saving hydrogen. However, the deactivation and detachment of active sites in powder electrocatalysts reported hitherto present significant challenges to achieving high efficiency and sustainability in energy-saving hydrogen production. Herein, a self-supported bimetallic nickel manganese metal-organic framework (NiMn-MOF) nanosheet and its derived heterostructure composed of NiMn-MOF decorated with ultrafine Pt nanocrystals (Pt/NiMn-MOF) are rationally designed.

A Novel Lysosome-Related Gene Signature Predicts Lung Cancer Prognosis: A Bioinformatics-Driven Study.

Background And Aims: The biological function of lysosomes has been increasingly appreciated in cancer. However, the relationship between lysosome and lung adenocarcinoma (LUAD) was not well understood. In this study, a lysosome-related signature was developed for LUAD risk stratification and prognosis prediction.

Corrigendum: Research progress of traditional Chinese medicine on the treatment of diarrhea by regulating intestinal microbiota and its metabolites based on renal-intestinal axis.

[This corrects the article DOI: 10.3389/fcimb.2024.

HAlign 4: a new strategy for rapidly aligning millions of sequences.

Motivation: HAlign is a high-performance multiple sequence alignment software based on the star alignment strategy, which is the preferred choice for rapidly aligning large numbers of sequences. HAlign3, implemented in Java, is the latest version capable of aligning an ultra-large number of similar DNA/RNA sequences. However, HAlign3 still struggles with long sequences and extremely large numbers of sequences.

Emerging trends and hotspots in intestinal microbiota research in sepsis: bibliometric analysis.

Background: The association between the gut microbiota and sepsis has garnered attention in the field of intestinal research in sepsis. This study utilizes bibliometric methods to visualize and analyze the literature on gut microbiota research in sepsis from 2011 to 2024, providing a scientific foundation for research directions and key issues in this domain.

Methods: Original articles and reviews of gut microbiota research in sepsis, which published in English between 2011 and 2024, were obtained from the Web of Science Core Collection on June 21, 2024.

Evaluation of Drug-Drug Interactions Between Clarithromycin and Direct Oral Anticoagulants Using Physiologically Based Pharmacokinetic Models.

This study assessed the pharmacokinetic (PK) interactions between clarithromycin (a P-glycoprotein [P-gp] inhibitor) and four direct oral anticoagulants (DOACs) (P-gp substrates) using physiologically based PK (PBPK) models to elucidate the influence of P-gp in the interaction between them. PBPK models for clarithromycin, DABE-dabigatran (DAB), rivaroxaban, apixaban, and edoxaban were constructed using GastroPlus™ (version 9.9), based on physicochemical data and PK parameters from the literature.

Effects of Different Types and Ratios of Dry Tea Residues on Nutrient Content, Rumen Fermentation, and the Bacterial Community of Ensiled Sweet Sorghum.

Dry tea residue is a byproduct generated during the production, processing, and storage of tea leaves. The active ingredients and microbial composition of dried tea residue vary depending on different tea processing techniques. This study investigated the effects of six processed dry tea residues-green tea (G), black tea (B), raw Pu'er tea (Z), white tea (W), and ripe Pu'er tea (D)-at two addition ratios (5% and 10%) on the nutritional composition, fermentation quality, fermentation, and bacterial community of sweet sorghum () in the ensiling process.

Gegen Qinlian Decoction improves H1N1-induced viral pneumonia by modulating the "gut microbiota-metabolomics-immune/inflammation" axis.

Background And Aim: The acute pulmonary infectious disease caused by influenza viruses is known as influenza virus pneumonia (IVP). In recent years, Gegen Qinlian Decoction (GQD) has been widely used to treat pulmonary inflammation; however, the underlying mechanism of action of GQD in IVP remains unclear. This study aimed to elucidate the molecular mechanism through which GQD improved IVP.

Scleromitrion diffusum (Willd.) R. J. Wang Inhibits Gastric Cancer via ERBB2/ERBB3/PI3K/AKT Pathway.

Background/aims: This study aimed to evaluate the anticarcinogenic potential of Scleromitrion diffusum (Willd.) R. J.

Visible-Light-Induced Rapid Elimination of Antibiotic Resistance Contaminations Using Graphitic Carbon Nitride Tailored with Carrier Confinement Domains.

Solar water disinfection facilitated by photocatalyst has been considered a viable point-of-use (POU) method for mitigating antibiotic resistance contaminations at the household or community levels. Here, density functional theory calculations are used to guide the fabrication of a carrier confinement domains (CCD)-decorated graphitic carbon nitride (CN) photocatalyst. The CCD integration effectively disrupts the electron distribution symmetry of CN, amplifies its local electron density, and facilitates the formation of long-range ordered structure, thereby enhancing charge separation efficiency.

Pr doping promotes the formation of Pt single atoms by regulating metal-support interaction for remarkable photocatalytic hydrogen production.

Since the metal-support interaction (MSI) has a great influence on the structure and properties of single atom catalysts (SACs), the activity and stability of SACs can be effectively regulated by adjusting the structure of the matrix. Herein, the morphology of surface supported Pt species can be controlled by doping to adjust the properties of TiO support. Specifically, under the same conditions, the Pt species on the Pr doped TiO surface are Pt SAs (Pt/TiO(Pr)), while on the pure TiO surface are particles (Pt/TiO).

Managing Edge States in Reduced-Dimensional Perovskites for Highly Efficient Deep-Blue LEDs.

Pure-halide reduced-dimensional perovskites, featuring large exciton binding energy and tunable bandgap, show great potential for high-efficiency deep-blue perovskite light-emitting diodes (PeLEDs). However, their efficiency, particularly in the low n-value phase domain ("n" represents the number of octahedral sheets), lags behind analogous perovskite emitters. Herein, it is demonstrated that the vibration of edge-dangling octahedra in the low n-value phase activates notorious exciton-phonon (EP) coupling, thereby deteriorating efficiency.

Mitochondrial small RNA alterations associated with increased lysosome activity in an Alzheimer's Disease Mouse Model uncovered by PANDORA-seq.

Emerging small noncoding RNAs (sncRNAs), including tRNA-derived small RNAs (tsRNAs) and rRNA-derived small RNAs (rsRNAs), are critical in various biological processes, such as neurological diseases. Traditional sncRNA-sequencing (seq) protocols often miss these sncRNAs due to their modifications, such as internal and terminal modifications, that can interfere with sequencing. We recently developed panoramic RNA display by overcoming RNA modification aborted sequencing (PANDORA-seq), a method enabling comprehensive detection of modified sncRNAs by overcoming the RNA modifications.

Cu surface plasmon resonance promoted charge transfer in S-scheme system enhanced visible light photocatalytic hydrogen evolution.

Reasonably constructing nanocomposite photocatalysts with fast charge transfer and broad solar response capabilities is significant for efficiently converting solar energy into chemical energy. Cu modifies P25/CeO heterojunctions prepared by photodeposition (P25 is commercial TiO). The local surface plasmon resonance (LSPR) effect caused by Cu nanoparticles broadens the spectral response range and generates significant photothermal effects.