Apigenin attenuated sepsis induced acute lung injury via polarizing macrophage towards M2 by blocking miR-146a →TLR7 interaction.

TLR7 (Toll-like receptor 7) has been indicated as an important sensor for single -stranded RNA contributes to systemic inflammation and mortality in acute lung injury (ALI), which is an acute diffuse inflammatory lung injury. Cumulative results show that macrophages contribute to the development and progression of ALI through the secretion of inflammatory cytokines/chemokines. Here we show that macrophage polarizes towards M1 phenotype and TLR7 signaling is activated in septic mice.

Omega-3 polyunsaturated fatty acids attenuates cognitive impairment via the gut-brain axis in diabetes-associated cognitive dysfunction rats.

Diabetes-related cognitive dysfunction (DACD) is a comorbidity of type 2 diabetes that has a negative effect on patients' quality of life. Research has indicated that disruption of the gut microbiota (GM) may be linked to dementia with altered cognitive performance. Conversely, omega-3 polyunsaturated fatty acids (n-3 PUFAs) may reverse DACD.

Top health service concerns: a data mining study of the Shanghai health hotline.

Objective: Our study aims to explore the health service issues of public concern through analyzing the basic characteristics of callers and information from the health hotline in Shanghai. The findings of this study will provide a reference to relevant government departments and assist the government in optimizing the allocation of health resources.

Methods: Our research utilized 16,962 original work orders from the 12,320 health hotline, collected since 2015.

Microbial dysbiosis with tryptophan metabolites alteration in lower respiratory tract is associated with clinical responses to anti-PD-1 immunotherapy in advanced non-small cell lung cancer.

Lower respiratory tract microbiome constitutes a unique immune microenvironment for advanced non-small cell lung cancer as one of dominant localized microbial components. However, there exists little knowledge on the associations between this regional microbiome and clinical responses to anti-PD-1 immunotherapy from clinical perspectives. Here, we equivalently collected bronchoalveolar lavage fluids from 56 advanced NSCLC participants treated with none (untreated, n = 28) or anti-PD-1 immunotherapy (treated, n = 28), which was further divided into responder (n = 17) and non-responder (n = 11) subgroups according to clinical responses, aiming to compare their microbial discrepancy by performing metagenomic sequencing and targeted metabolic alterations by tryptophan sequencing.

Vapour-liquid-solid-solid growth of two-dimensional non-layered β-BiO crystals with high hole mobility.

Currently, p-type two-dimensional (2D) materials lag behind n-type ones in both quantity and performance, hindering their use in advanced p-channel transistors and complementary logic circuits. Non-layered materials, which make up 95% of crystal structures, hold the potential for superior p-type 2D materials but remain challenging to synthesize. Here we show a vapour-liquid-solid-solid growth of atomically thin (<1 nm), high-quality, non-layered 2D β-BiO crystals on a SiO/Si substrate.

Safe CNV removal is crucial for successful hESC-RPE transplantation in wet age-related macular degeneration.

Subretinal transplantation of human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells has demonstrated therapeutic potential in macular degeneration. However, its efficiency is limited in wet age-related macular degeneration (wet AMD) due to choroidal neovascularization (CNV). To investigate the feasibility of hESC-RPE cell transplantation, we employed a surgical approach to induce retinal detachment, which allowed the removal of CNV lesions.

Identification of E3 ubiquitin ligase-based molecular subtypes and prognostic signature regarding prognosis and immune landscape in bladder cancer.

E3 ubiquitin ligases are acknowledged as the principal catalysts in the ubiquitination process due to their capacity to identify, bind and recruit specific substrates for modification. However, knowledge about the expression patterns of E3 ligases and their contribution to the tumor heterogeneity of bladder cancer (BLCA) is still lacking. Here, we delineated two distinct subcategories of BLCA utilizing consensus clustering of variable expression patterns of E3 ligases from the TCGA database, outlining the functional characteristics and immune profiles of these subclusters.

RNA interference-mediated silencing of GNBP2 reduces the immunity of stored pest Tribolium castaneum against bacteria.

Gram-negative bacteria binding proteins (GNBPs) are involved in regulating the immune response of insects. The information on functions and mechanisms of insect GNBPs in innate immunity will contribute to biological control of pests. Tribolium castaneum is a serious, world-wide pest damaging stored food and feed products.

Sludge water: a potential pathway for the spread of antibiotic resistance and pathogenic bacteria from hospitals to the environment.

Hospitals play an important role in the spread of antibiotic resistance genes (ARGs) and antimicrobial resistance (AMR). The ARGs present in hospital wastewater tend to accumulate in activated sludge, with different ARGs exhibiting varying migration rates. As a result, sludge water produced during the activated sludge treatment process may be a significant source of ARGs entering the environment.

Sodium Butyrate Alleviates Heat Stress-Induced Oxidative Stress and Skeletal Muscle Homeostasis Disruption by Promoting Autophagy in Mice.

Background: The gradual rise in global temperatures can affect skeletal muscle development and intestinal microorganisms. However, the influence of microbial metabolites on skeletal muscle homeostasis under heat stress (HS) remains unclear.

Methods: C57BL/6J mice were exposed to normal temperature or 40 °C conditions for 3 d, 7 d, or 14 d.

Research on PVDF/BNNSs/MXene multilayer films with high energy density and thermal conductivity for dielectric capacitors.

Polyvinylidene fluoride (PVDF) has promising applications in the field of dielectric capacitors. However, its low dielectric constant and thermal conductivity limit energy storage density. To address this, three multilayer composite topologies were designed with PVDF/boron nitride nanosheets as insulation and PVDF/MXene as polarization layers.

Semicircular Canals Input Can Modify the Fast-Phase Nystagmus in Off-Vertical Axis Rotation of Mice.

Vestibular research is essential for understanding and treating disorders such as vertigo and Meniere's disease. The vestibulo-ocular reflex (VOR) is a key method for assessing vestibular function and an essential tool for diagnosing vertigo. Traditionally, the VOR comprises angular VOR (aVOR) and translational VOR (tVOR), which originate from the vestibular semicircular canals (SCCs) and otolith organs, respectively.

Protective and risk factors in problematic mobile phone use among adolescents: A three-wave longitude study.

Adolescents' problematic mobile phone use (PMPU) has become increasingly severe. This study examined the changes in relationships between dimensions of PMPU, protective (positive psychological capital, i.e.

Investigation of Dielectric Barrier Discharge Plasma for the Degradation of Erythromycin Solution.

Antibiotic contamination constitutes a serious environmental and public health risk. In order to fill the gap in the study of plasma degradation of erythromycin (ERY), this paper systematically investigated the mechanism of ERY degradation by dielectric barrier discharge (DBD) plasma. The underlying reaction mechanisms were investigated by experiments and molecular dynamics simulations.

Ecological drought sensitivity assessment of winter wheat in the Huang-Huai-Hai plain, China.

Drought events are complex and uncertain, and drought sensitivity assessments are beneficial for ecological conservation and improving early warning mechanisms. Understanding ecosystems' response to drought is vital for ecological conservation and climate change research. Ecological drought, a concept describing drought from an ecosystem perspective, lacks sufficient research regarding its effects on agricultural ecosystems, especially in the Huang-Huai-Hai Plain.

Bisphenol A attenuates testosterone synthesis via increasing apolipoprotein A1-mediated reverse cholesterol transport in mice.

Bisphenol A (BPA), a widely used chemical compound in plastic manufacturing, has become ubiquitous in the environment. Previous studies have highlighted its adverse effects on reproductive function, as BPA exposure reduces testosterone levels. Cholesterol is involved in testosterone synthesis in Leydig cells.

Clostridia enhances intestinal immunity to alleviate ovalbumin-induced allergy.

Introduction: This study aimed to explore the effect of Clostridia administration on ovalbumin (OVA)-induced allergy and the relevant underlying mechanism in BALB/c mice.

Methods: Female BALB/c mice were assigned to three groups: control (C), OVA sensitization (CO), and intervention (IG). All mice were treated with antibiotics to eliminate their intestinal flora.

Chitosan cryogels incorporated with phytic acid-modified UiO-66-NH for enhanced flame-retardant performance.

In this work, chitosan (CS) was used as the skeleton to synthesize flame-retardant composite cryogels. Phytic acid (PA)-modified Zr-based metal-organic framework (PA-UiO-66-NH) was integrated into the CS network to enhance flame retardant performance. The vertical combustion test (UL-94) grade was V-0, and the limiting oxygen index (LOI) value reached 39 % when the flame retardant (PA-UiO-66-NH) addition content was 15 %.

Workplace violence, psychopathological symptoms, and deviant workplace behavior among nursing interns in China: a network analysis.

Background: Workplace violence in healthcare has become a global concern, and nursing interns are not immune to it in clinical settings. It is critical to understand the impact of workplace violence on the psychological and work status of nursing interns.

Methods: Between April and May 2024, a total of 2213 nursing interns from 12 hospitals in China participated in the study.

Putative Transformation Mechanism of γ-l-Glutamyl-S-Allyl-l-Cysteine during the Processing of Black Garlic.

γ-l-Glutamyl-S-allyl-l-cysteine (GSAC) is renowned for its flavor-modifying effects and beneficial biological activities. However, the level of GSAC decreases significantly during the processing of black garlic, and the pathways and degradation products resulting from this decline remain unclear. To investigate the potential transformation mechanisms of GSAC in black garlic, simulation systems for thermal decomposition, Maillard reactions, and enzymatic hydrolysis were established.

Pickering emulsion stabilized by hollow Zein/SSPS nanoparticles loaded with Thymol: Formation, characterization, and application in fruit preservation.

Using Pickering emulsion (PE) as the carrier of active compounds in bio-based coatings constitutes a highly promising research domain. This study focused on creating a food-grade, biocompatible, and antibacterial PE to coat fresh fruits and vegetables, extending their shelf life. Hollow zein/soluble soybean polysaccharide nanoparticles loaded with thymol (H-ZSH/T) were produced using NaHCO as a sacrificial template to stabilize PE.

Molecular Design for Dual Circularity: Polyester with Complementary Mechanical and Chemical Recyclability under Mild Conditions.

The plastic waste accumulation requires facile yet effective solutions. Currently mechanical recycling typically leads to downcycling, while the environmental footprint of chemical recycling is often unacceptable. Here, we introduce a dual circularity concept, where rational molecular design paves the way for complementary closed-loop mechanical and chemical recyclability under mild conditions.

Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition.

Bisphenol A (BPA) is a common endocrine disruptor chemical that is widely used in the production of food plastic packaging, and it has been shown to potentially harm the reproductive system. However, the specific mechanism by which BPA induces apoptosis of Leydig cells (LCs) and inhibits testosterone synthesis in these cells is unclear. In the present study, TM3 cells were used as an experimental model in combination with a reactive oxygen species (ROS) scavenger (N-acetylcysteine), Caspase-3 inhibitor (Ac-DEVD-CHO), autophagy activator (Torin2), and autophagy inhibitor (Chloroquine) to investigate the potential mechanisms by which BPA causes TM3 cell damage in vitro.

Genome-Wide Scans for Selection Signatures in Ningxia Angus Cattle Reveal Genetic Variants Associated with Economic and Adaptive Traits.

The genetic improvement of beef cattle breeds is crucial for the advancement of the beef cattle industry. Whole-genome resequencing technology has been widely applied in genetic breeding as well as research on selection signatures in beef cattle. In this study, 20× whole-genome resequencing was performed on 282 Angus cattle from the Ningxia region, and a high-quality dataset encompassing extensive genomic variations across the entire genome was constructed.

Photodynamic therapy-induced precise attenuation of light-targeted semicircular canals for treating intractable vertigo.

Vertigo is a common symptom of various diseases that affects a large number of people worldwide. Current leading treatments for intractable peripheral vertigo are to intratympanically inject ototoxic drugs such as gentamicin to attenuate the semicircular canal function but inevitably cause hearing injury. Photodynamic therapy (PDT) is a noninvasive therapeutic approach by precisely targeting the diseased tissue.