Construction of a public health practice teaching quality evaluation system based on the CIPP model using the Analytic Hierarchy Process (AHP) and entropy weight method.

Objective: This study aims to establish a comprehensive evaluation system for assessing public health practice teaching quality, addressing the shortcomings of traditional evaluation methods. The framework integrates the Context, Input, Process, and Product (CIPP) model with the Analytic Hierarchy Process (AHP) and Entropy Weight Method to provide precise and balanced weightings for evaluation indicators. AHP was selected for its ability to incorporate expert judgment with consistency checks, ensuring structured decision-making, while the Entropy Weight Method enhances objectivity by assigning weights based on data variability, reducing potential biases in expert evaluations.

Wheat MAPK cascade mediates SGT1 nuclear entry targeted by a stripe rust effector.

Mitogen-activated protein kinase (MAPK) cascades play a fundamental role in plant immunity by transducing external signals inside plant cells. Here, we defined a wheat MAPK cascade, composed of the mitogen-activated protein kinase kinase (MAPKK) TaMKK2 and its downstream MAPK TaMAPK6, which phosphorylates the core immune regulator TaSGT1 (suppressor of G2 allele of Skp1), resulting in enhanced nuclear entry of TaSGT1, thereby conferring resistance against the devastating wheat pathogen Puccinia striiformis f. sp.

Anionic polyelectrolyte-regulated cellulose nanocrystal-based hydrogels for controllable drug release.

The application of inorganic salt-regulated Hofmeister effects in cellulose nanocrystals (CNC)-based hydrogels is hindered by limitations, including poor biocompatibility and difficulties in achieving precise drug release. In this study, we show that the anionic polyelectrolyte regulated Hofmeister effect promotes the aggregation and crystallization of CNC and polyvinyl alcohol (PVA) chains. This structural transformation significantly enhances the controllability of drug release in CNC-based hydrogels.

The association of social deprivation index and contraception care in a statewide contraceptive access initiative.

Objectives: To examine the association of social deprivation index (SDI) and contraception care in a statewide contraceptive access initiative (PATH4YOU) in Indiana.

Study Design: A cross-sectional analysis was performed to examine associations of participant's chosen appointment type and contraceptive method with age and SDI.

Results: Of the 1201 participants, 45.

Association between social capital and trajectories of cognitive function among Chinese older adults.

Background: The association between social capital and trajectories of cognitive function (CF) is still unclear among older adults in mainland China. The present study aims to examine the association using a longitudinal cohort from the Ningxia Healthy Aging Cohort.

Methods: Four waves of longitudinal data were abstracted to identify the CF trajectories using the conditional latent class growth model (LCGM).

A ternary deep eutectic solvent for efficient biomass fractionation and lignin stabilization.

The efficient isolation and lignin stabilization are critical to the fractionation process of lignocellulosic biomass, enabling the subsequent valorization of both carbohydrates and lignin. In this study, a ternary deep eutectic solvent pretreatment system with outstanding reusability has been developed. Under optimal conditions (ChCl: MT: p-TsOH = 1:1:0.

Impaired interhemispheric synchrony in patients with iridocyclitis and classification using machine learning: an fMRI study.

Background: This study examined the interhemispheric integration function pattern in patients with iridocyclitis utilizing the voxel-mirrored homotopic connectivity (VMHC) technique. Additionally, we investigated the ability of VMHC results to distinguish patients with iridocyclitis from healthy controls (HCs), which may contribute to the development of objective biomarkers for early diagnosis and intervention in clinical set.

Methods: Twenty-six patients with iridocyclitis and twenty-six matched HCs, in terms of sex, age, and education level, underwent resting-state functional magnetic resonance imaging (fMRI) examinations.

The Interplay of Systemic Inflammation and Oxidative Stress in Connecting Perirenal Adipose Tissue to Hyperuricemia in Type 2 Diabetes Mellitus: A Mediation Analysis.

Background: Emerging evidence suggests that increased perirenal adipose tissue (PAT) may trigger systemic inflammation and oxidative stress, potentially contributing to hyperuricemia (HUA). This study aimed to explore the link between PAT and HUA risk, and the potential mediating role of inflammation and oxidative stress.

Methods: This study recruited 903 participants with T2DM.

Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood.

Background & Aims: Mood disorders and disorders of gut-brain interaction (DGBI) are highly prevalent, commonly comorbid, and lack fully effective therapies. Although selective serotonin reuptake inhibitors (SSRIs) are first-line pharmacological treatments for these disorders, they may impart adverse effects, including anxiety, anhedonia, dysmotility, and, in children exposed in utero, an increased risk of cognitive, mood, and gastrointestinal disorders. SSRIs act systemically to block the serotonin reuptake transporter and enhance serotonergic signaling in the brain, intestinal epithelium, and enteric neurons.

Targeting programmed cell death via active ingredients from natural plants: a promising approach to cancer therapy.

Cancer is a serious public health problem in humans, and prevention and control strategies are still necessary. Therefore, the development of new therapeutic drugs is urgently needed. Targeting programmed cell death, particularly via the induction of cancer cell apoptosis, is one of the cancer treatment approaches employed.

Electroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the β adrenergic receptor and post-receptor protein kinase A signaling pathway.

Objective: To determine the effect of electroacupuncture (EA) on β-adrenergic receptor (β-AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).

Methods: An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57/BL and β-AR mice (heterozygous for β-AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8.

Single-Cell Multi-Omics Analysis of In Vitro Post-Ovulatory-Aged Oocytes Revealed Aging-Dependent Protein Degradation.

Once ovulated, the oocyte has to be fertilized in a short time window or it will undergo post-ovulation aging (POA), whose underlying mechanisms are still not elucidated. Here, we optimized single-cell proteomics methods and performed single-cell transcriptomic, proteomic, and phosphoproteomic analysis of fresh, POA, and melatonin-treated POA oocytes. POA oocytes showed downregulation of most differentially expressed proteins, with little correlation with mRNA expression, and the protein changes can be rescued by melatonin treatment.

Autonomous self-healing and superior tough polyurethane elastomers enabled by strong and highly dynamic hard domains.

Self-healing materials show exceptional application potential for their high stability and longevity. However, a great challenge of the application of self-healing materials is the tradeoff between mechanical robustness and room temperature self-healing. In order to address this tradeoff, inspired by the characteristic that small molecules of living organisms self-assemble into large protein molecules by non-covalent interactions, we constructed polyurethane with highly dynamic and strong hard domains composed of dense hydrogen bonds and π-π interactions between the phenylurea groups at the end of the side chain.

TL-CStrans Net: a vision robot for table tennis player action recognition driven via CS-Transformer.

Currently, the application of robotics technology in sports training and competitions is rapidly increasing. Traditional methods mainly rely on image or video data, neglecting the effective utilization of textual information. To address this issue, we propose: TL-CStrans Net: A vision robot for table tennis player action recognition driven via CS-Transformer.

The road to inclusive green growth in China: Exploring the impact of digital-real economy integration on carbon emission efficiency.

With the emergence of digital transformation, China confronts the dual challenge of fostering sustainable economic and social development while fulfilling its "dual-carbon" commitments. Is the digital-real economy integration a blessing or a curse for inclusive green development? The study was conducted under this backdrop. This paper explores the impacts and mechanisms of digital-real economy integration on carbon emission efficiency, utilizing panel data from 274 Chinese cities over the period from 2011 to 2021.

Generation and characterization of a novel ovariole cell line derived from Spodoptera frugiperda in China with sensitivity to both SfMNPV and AcMNPV.

Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV), belonging to the species Alphabaculovirus spofrugiperdae, has been recently registered as an insecticide in China. This virus has a specific effect on the global major agricultural pest Spodoptera frugiperda. To gain insights into viral infection, replication processes, and the complex formation of viral particles, in vitro studies using cell lines are essential tools.

Atom-Economic Synthesis of Zeolites.

Zeolites are typically synthesized in the presence of strong alkaline or fluoride species, which is not atom-economic for zeolite synthesis due to the high solubility of strong alkaline and fluoride species to silica. One of the solutions for this issue is to reduce solubility of silica in the zeolite synthesis, but it is challenging. Herein, we show that nucleation and growth of zeolites can occur under near neutral conditions, giving an atom-economical synthesis of zeolites with almost full silica utilization due to very low silica solubility.

Lake-centred sedentary lifestyle of early Tibetan Plateau Indigenous populations at high elevation 4,400 years ago.

The onset of sedentism on the Tibetan Plateau is often presumed to be associated with the dispersal of agriculture or farmers from archaeological sites located in the low elevation margins of the plateau. Previous studies of the plateau assumed that all foragers were probably mobile, but few systematic excavations at forager sites have been conducted to inform us about their settlement patterns. Here we report the world's highest elevation sedentary way of living exhibited by the Mabu Co site at 4,446 metres above sea level, deep in the interior of the Tibetan Plateau 4,400-4,000 years ago.

Virulent Effector Hasp155 of f. sp. Suppresses Plant Immunity and Promotes Fungus Infection.

As a kind of obligate biotrophic fungus, f. sp. () secretes vast effectors via haustoria to host cells during the infection to inhibit host defense responses and promote fungal invasion.

Insight into the Kinetics of Isomerization and β-Scission Reactions Following H-Abstraction in 2-Pentanone Combustion.

2-Pentanone is a significant carbon-neutral fuel. To better understand 2-pentanone combustion, the CCSD(T)/CBS method was used to calculate the potential energy surfaces (PES) for H-abstraction, isomerization, and β-scission reactions of 2-pentanone. Rate constants for the above reactions were calculated by the MESS employing conventional transition state theory (CTST) at 300-2000 K.