Moral Believer or Moral Problem-Solver? Moral Pragmatism Fosters Tolerance Without Impeding Moral Behavior.

Many previous studies in moral psychology have described people as moral believers, who treat morality as universal sacred beliefs and show moral outrage and social exclusion toward people with different opinions. At the same time, moral relativism tends to make people more tolerant but also makes them question their own beliefs and leads to more immoral behavior. We propose moral pragmatism as an alternative, which treats morality as a tool for solving specific problems, thus making morality situational instead of universal, practical instead of sacred, and tolerant instead of exclusive.

Effects of self-compassion on aggression and its psychological mechanism through perceived stress.

Given the increasing global concerns about aggressive behaviors and the pressing need for effective psychological interventions, this study delves into the potential of a concept deeply rooted in positive and Buddhist psychology but largely researched in Western contexts, as a mitigating factor against aggression in Chinese adults. Through three core studies involving 652 participants (age: 30.52±8.

Structure of phosphorylated-like RssB, the adaptor delivering σ to the ClpXP proteolytic machinery, reveals an interface switch for activation.

In enterobacteria such as Escherichia coli, the general stress response is mediated by σ, the stationary phase dissociable promoter specificity subunit of RNA polymerase. σ is degraded by ClpXP during active growth in a process dependent on the RssB adaptor, which is thought to be stimulated by the phosphorylation of a conserved aspartate in its N-terminal receiver domain. Here we present the crystal structure of full-length RssB bound to a beryllofluoride phosphomimic.

Effects of Robot Animacy and Emotional Expressions on Perspective-Taking Abilities: A Comparative Study across Age Groups.

The global population is inevitably aging due to increased life expectancy and declining birth rates, leading to an amplified demand for innovative social and healthcare services. One promising avenue is the introduction of companion robots. These robots are designed to provide physical assistance as well as emotional support and companionship, necessitating effective human-robot interaction (HRI).

G-CN sheet nanoarchitectonics with island-like crystalline/amorphous homojunctions towards efficient H and HO evolution.

Photocatalystic evolution of HO from water and oxygen has attracted significant attention because of environmentally friendly. The absorption in visible and hydrophilic feature of graphitic carbon nitride (g-CN) make it a good candidate. In this paper, a rapid post-treatment at high temperature was developed to obtain g-CN nanosheets with abundant crystalline/amorphous interfaces to form homojunctions, which optimized uniplanar carrier mobility dynamics.

Association between monocyte lymphocyte ratio and abdominal aortic calcification in US adults: A cross-sectional study.

Background: This study aimed to evaluate the association between Monocyte Lymphocyte Ratio (MLR) and Abdominal Aortic Calcification (AAC) in adults over 40 years of age in the United States.

Methods: Data were collected from the 2013-2014 National Health and Nutrition Examination Survey (NHANES). AAC was quantified by the Kauppila score system based on dual-energy X-Ray absorptiometry.

The effects of the prognostic biomarker SAAL1 on cancer growth and its association with the immune microenvironment in lung adenocarcinoma.

Background: Inhibition of Serum Amyloid A-like 1 (SAAL1) expression could inhibit cancer progression and improve the prognosis of cancer patients. At present, the correlation between SAAL1 and lung adenocarcinoma (LAC) remains unclear. Therefore, this study surveyed the worth and pathway of SAAL1 in LAC progression and immunity.

Multi Stimuli-Responsive Aggregation-Induced Emission Active Polymer Platform Based on Tetraphenylethylene-Appended Maleic Anhydride Terpolymers.

Multi stimuli-responsive aggregation-induced emission (AIE) active polymers have great application prospects in high-tech innovations. Herein, three types of tetraphenylethylene (TPE)-containing monomers were synthesized and utilized in preparing TPE-appended maleic anhydride terpolymers. After hydrolysis, the produced TPE-appended maleic acid terpolymers have identical linear charge densities but different "primary" structures, which created widely varied microenvironments around the carboxylate and TPE groups.

Downregulation of T-cell cytotoxic marker IL18R1 promotes cancer proliferation and migration and is associated with dismal prognosis and immunity in lung squamous cell carcinoma.

Immunotherapy can improve the survival of patients with advanced lung squamous cell carcinoma (LUSC). T cytotoxic cells are one of the main members of the immune microenvironment. Herein, we aimed to identify the roles of T-cell cytotoxic markers interleukin 18 (IL18) receptor 1 (IL18R1) in the LUSC progression using bioinformatics, clinical tissue specimen, and cell experiment.

A positive feedback loop of heparanase/syndecan1/nerve growth factor regulates cancer pain progression.

Background: The purpose of this research was to assess the role of heparanase (HPSE)/syndecan1 (SDC1)/nerve growth factor (NGF) on cancer pain from melanoma.

Methods: The influence of HPSE on the biological function of melanoma cells and cancer pain in a mouse model was evaluated. Immunohistochemical staining was used to analyze HPSE and SDC1.

TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma.

The roles and mechanisms of T-cell receptor (TCR)-associated transmembrane adaptor 1 (TRAT1) in lung adenocarcinoma (LAC) have not yet been reported in the relevant literature. Therefore, this study aimed to understand the roles and mechanisms of TRAT1 in LAC using bioinformatics and experiments. TRAT1 expression levels in LAC samples were analysed using various databases.

The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer.

Objective: T cell receptor-associated transmembrane adaptor 1 (TRAT1) is one of the hub genes regulating T cell receptors (TCRs). Herein, the roles of TRAT1 in the prognosis and immune microenvironment of non-small cell lung cancer (NSCLC) were investigated.

Methods: The expression and prognosis values of TRAT1 in NSCLC, and the relationship between TRAT1 expression levels and cancer immune cell infiltration was identified via the TIMER, UALCAN, TISIDB, and other databases.

Free volume dependence of the dielectric constant of poly(vinylidene fluoride) nanocomposite films.

The free volume effects on the dielectric properties of the polymer are ambiguous, and the quantitative effect of free volume on the dielectric properties has rarely been systematically studied, especially in the high-elastic state dipolar (HESD) polymer. In this work, the free volume of dipolar poly(vinylidene fluoride) (PVDF) is regulated by the addition of AlO, which greatly increase the size of free volume holes. Then the effect of free volume on the dielectric properties of PVDF/AlO composites is discussed.

Optimizing nanostructures to achieve enhanced breakdown strength and improved energy storage performances in dipolar polymers.

Polymer dielectrics have attracted ever-increasing attention for electrical energy storage applications in recent years. Typically, polymer-based nanocomposite films are adopted to obtain polymer dielectrics with high energy density but sometime suffer from the inhomogeneous distribution of fillers. In this work, enhanced breakdown strength, suppressed dielectric loss and improved energy storage performances of PVDF film are concurrently achieved the regulation of the sub-nano free volume, without introduction of any kinds of fillers and also minimizing the uneven distribution of the local electric field.

Clinical Roles of Risk Model Based on Differentially Expressed Genes in Mesenchymal Stem Cells in Prognosis and Immunity of Non-small Cell Lung Cancer.

The tumor microenvironment (TME) plays an important regulatory role in the progression of non-small cell lung cancer (NSCLC). Mesenchymal stem cells (MSCs) in the TME might contribute to the occurrence and development of cancer. This study evaluates the role of differentially expressed genes (DEGs) of MSCs and the development of NSCLC and develops a prognostic risk model to assess the therapeutic responses.

Bifunctional Nitrogen-Doped Carbon Dots in g-CN/WO Heterojunction for Enhanced Photocatalytic Water-Splitting Performance.

A novel metal-free all-solid-state z-scheme g-CN/NCDs/WO photocatalyst was fabricated using nitrogen-doped carbon dots (NCDs) as the electron mediator. As-prepared sandwich-structured composites displayed enhanced visible and NIR light photocatalytic activity. Under visible light irradiation, the hydrogen evolution rate reached 3.

Free volume dependence of dielectric behaviour in sandwich-structured high dielectric performances of poly(vinylidene fluoride) composite films.

A dielectric film with a trilayer structure is fabricated to obtain both a high dielectric constant and superior electrical breakdown strength simultaneously. The outer layers of the trilayered composite film are composed of barium titanate (BTO) particles dispersed in poly(vinylidene fluoride) (PVDF) to ensure a relatively high dielectric constant, while the central layer of the composite film consists of exfoliated hexagonal boron nitride nanosheets (BNNS) dispersed in PVDF to provide high electrical breakdown strength. Compared with pristine PVDF, the dielectric constant and breakdown strength are simultaneously enhanced due to the sandwich structure, and the dielectric loss is maintained at a low level.

Putative ratios of facial attractiveness in a deep neural network.

Empirical evidence has shown that there is an ideal arrangement of facial features (ideal ratios) that can optimize the attractiveness of a person's face. These putative ratios define facial attractiveness in terms of spatial relations and provide important rules for measuring the attractiveness of a face. In this paper, we show that a deep neural network (DNN) model can learn putative ratios from face images based only on categorical annotation when no annotated facial features for attractiveness are explicitly given.

The importance of overweight in COVID-19: A retrospective analysis in a single center of Wuhan, China.

The aim of this study was to evaluate the association between overweight and severity, drug response, and clinical outcomes of novel coronavirus disease 2019 (COVID-19).In this retrospective cohort study, we reviewed medical records of 240 COVID-19 patients admitted to Union Hospital in Wuhan, China, between December 24, 2019, and March 25, 2020. Physical, clinical, laboratory, radiological characteristics, treatment, and outcome data were abstracted.

Chemoproteomic Profiling of an Ibrutinib Analogue Reveals its Unexpected Role in DNA Damage Repair.

Ibrutinib is an FDA-approved drug to treat B-lymphoid malignancies, which functions mechanistically as a covalent inhibitor for Bruton's tyrosine kinase (BTK). During the course of screening more potent and selective BTK inhibitors, we discovered that MM2-48, an ibrutinib analogue that contains the alkynyl amide functional group in place of the acrylamide warhead, exhibits a much stronger cytotoxicity. Comparative chemoproteomic profiling of the targets of ibrutinib and MM2-48 revealed that the alkynyl amide warhead exhibits much higher reactivity in proteomes.

Decreased prealbumin level is associated with increased risk for mortality in elderly hospitalized patients with COVID-19.

Objectives: High-risk patients ≥65 y of age with coronavirus disease 2019 (COVID-19) tended to have lower serum prealbumin concentrations. The aim of this study was to investigate the association of prealbumin at baseline on COVID-19-related mortality in elderly patients (≥65 y of age).

Methods: We non-selectively and consecutively collected participants from Tongji Hospital in Wuhan from January 17 to February 17, 2020.

Ribavirin therapy for severe COVID-19: a retrospective cohort study.

The aim of this study was to compare ribavirin therapy versus supportive therapy only for patients with severe coronavirus disease 2019 (COVID-19). A total of 115 patients with laboratory-confirmed COVID-19 were retrospectively analysed. All patients received supportive care as well as regular laboratory and clinical monitoring.

WO horizontally-grown on TiO(B) nanosheets for enhanced photo- and electro-chemical activity.

WO was deposited on TiO(B) nanosheets prepared using TiCl to form layered heterostructures via a two-step solvothermal synthesis, in which the horizontal growth of WO on TiO(B) nanosheets was carried out using WCl and ascorbic acid as a reducer. Optimized preparation conditions allowed WO/TiO(B) layered heterostructures to be formed. The photo- and electro-chemical properties of layered heterostructures depended strongly on the amount of WO.

Predictive factors for disease progression in hospitalized patients with coronavirus disease 2019 in Wuhan, China.

Background: A few studies have revealed the clinical characteristics of hospitalized patients with COVID-19. However, predictive factors for the outcomes remain unclear.

Objective: Attempted to determine the predictive factors for the poor outcomes of patients with COVID-19.