A single-center study examining the safety and effectiveness of ERCP with pancreatoscopy and endoluminal radiofrequency ablation for main-duct IPMN treatment.

To assess the safety and efficacy of treatment for intraductal papillary mucinous neoplasm (IPMN) involving the main pancreatic duct (MPD) using endoscopic retrograde cholangiopancreatography (ERCP) combined with digital single-operator pancreatoscopy and radiofrequency ablation (RFA). A retrospective analysis was performed. Patients with episodes of acute pancreatitis at the First Affiliated Hospital of Chongqing Medical University were screened.

Effects of environmentally relevant concentrations of citalopram in freshwater mesocosms.

Increased pharmaceutical usage has led to their widespread presence in aquatic environments, resulting in concerns regarding their potential environmental impacts. Antidepressants, particularly selective serotonin reuptake inhibitors (SSRIs) like citalopram, are frequently detected in European surface waters. Acute laboratory studies have demonstrated that citalopram can inhibit algal growth, immobilise Daphnia magna, and may result in foot detachment (i.

Overall Description and Predictors of Disruptive Behavior Toward Nurses in the Perioperative Arena.

Purpose: To investigate the prevalence, characteristics, causes, consequences, and predictors of and responses to disruptive behavior toward nurses in the perioperative arena.

Design: A cross-sectional design using a network questionnaire platform.

Methods: Nurses in the perioperative arena were recruited online in March 2020.

Environmental distribution and genomic characteristics of , with proposal of two novel species.

spp. were abundant in soil samples collected from deserts and other areas with high UV radiation. In addition, a novel species, with strain CPCC 204708 as the type, was isolated and identified from sandy soil sample collected from the Badain Jaran Desert of the Inner Mongolia autonomous region.

Establishment of a prognostic signature based on fatty acid metabolism genes in HCC associated with hepatitis B.

Background: Hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) is one of the most common and deadly cancer and often accompanied by varying degrees of liver damage, leading to the dysfunction of fatty acid metabolism (FAM). This study aimed to investigate the relationship between FAM and HBV-associated HCC and identify FAM biomarkers for predicting the prognosis of HBV-associated HCC.

Methods: Gene Set Enrichment Analysis (GSEA) was used to analyze the difference of FAM pathway between paired tumor and adjacent normal tissue samples in 58 HBV-associated HCC patients from the Gene Expression Omnibus (GEO) database.

Characterization of three rapidly growing novel species with significant polycyclic aromatic hydrocarbon bioremediation potential.

species exhibit high bioremediation potential for the degradation of polycyclic aromatic hydrocarbons (PAHs) that are significant environmental pollutants. In this study, three Gram-positive, rapidly growing strains (YC-RL4, MB418, and HX176) were isolated from petroleum-contaminated soils and were classified as within the family . Genomic average nucleotide identity (ANI; < 95%) and digital DNA-DNA hybridization (dDDH; < 70%) values relative to other spp.

Improved Electrocatalytic Activity and Stability by Single Iridium Atoms on Iron-based Layered Double Hydroxides for Oxygen Evolution.

Full understanding to the origin of the catalytic performance of a supported nanocatalyst from the points of view of both the active component and support is significant for the achievement of high performance. Herein, based on a model electrocatalyst of single-iridium-atom-doped iron (Fe)-based layered double hydroxides (LDH) for oxygen evolution reaction (OER), we reveal the first completed origin of the catalytic performance of such supported nanocatalysts. Specially, besides the activity enhancement of Ir sites by LDH support, the stability of surface Fe sites is enhanced by doped Ir sites: DFT calculation shows that the Ir sites can reduce the activity and enhance the stability of the nearby Fe sites; while further finite element simulations indicate, the stability enhancement of distant Fe sites could be attributed to the much low concentration of OER reactant (hydroxyl ions, OH ) around them induced by the much fast consumption of OH on highly active Ir sites.

Case report: Single-operator peroral cholangioscopy system (SpyGlass) diagnosis of an extrahepatic biliary cystadenoma (video).

Biliary cystadenoma is a type of rare liver cystic tumor. Intrahepatic biliary cystadenomas are the most common, while extrahepatic biliary cystadenomas are rarely seen. Biliary cystadenoma tends to occur in middle-aged to older women and there is a lack of specific preoperative diagnostic markers.

Research on Hysteretic Behavior of FRP-Confined Concrete Core-Encased Rebar.

FRP-confined concrete core-encased rebar (FCCC-R) is a novel composite structure that has recently been proposed to effectively delay the buckling of ordinary rebar and enhance its mechanical properties by utilizing high-strength mortar or concrete and an FRP strip to confine the core. The purpose of this study was to study the hysteretic behavior of FCCC-R specimens under cyclic loading. Different cyclic loading systems were applied to the specimens and the resulting test data were analyzed and compared, in addition to revealing the mechanism of elongation and mechanical properties of the specimens under the different loading systems.

Experimental and Numerical Investigation of Axial Compression Behaviour of FRP-Confined Concrete-Core-Encased Rebar.

The axial compression behaviour of fibre-reinforced polymer (FRP)-confined concrete-core-encased rebar (FCCC-R) was investigated by performing monotonic axial compression tests on seven groups of FCCC-R specimens and three groups of pure rebar specimens. The research parameters considered were the FRP winding angle (0°, ±45°, and 90°), number of layers (2, 4, and 6 layers), and slenderness ratio of specimens (15.45, 20, and 22.

LncRNA RPPH1 acts as a molecular sponge for miR-122 to regulate Wnt1/β-catenin signaling in hepatocellular carcinoma.

This study aimed to explore the role of lncRNA RPPH1 in hepatocellular carcinoma. The expression of RPPH1 and miR-122 was determined by Real-time PCR. Cell proliferation and colony formation assays were employed to monitor cell growth .

Hepatocyte-derived exosomes deliver H2AFJ to hepatic stellate cells and promote liver fibrosis via the MAPK/STMN1 axis activation.

Hepatic stellate cells (HSCs) activate and acquire proliferative features in response to liver injury. However, mechanisms involved in the activation of fibrotic HSCs remain uncharacterized. This study aims at elaborating the mechanistic basis by which exosomal H2AFJ derived from hepatocytes might affect the activation of HSCs and liver fibrosis.

Malnutrition diagnosed by the Global Leadership Initiative on Malnutrition criteria predicting survival and clinical outcomes of patients with cancer: A systematic review and meta-analysis.

Objectives: Recently, some cohorts have looked into the use of Global Leadership Initiative on Malnutrition (GLIM) criteria in cancer patients. The objective of the current meta-analysis was to determine its utility in predicting clinical and survival outcomes for cancer patients.

Method: Searching and screening literature from PubMed, Web of Science and Embase until September 13, 2022 was performed by two researchers independently.

Predictive Theoretical Model for the Selective Electroreduction of Nitrate to Ammonia.

The electrochemical reduction of nitrate (eNORR) emerges as a promising route for decentralized ammonia synthesis. However, the competitive production of nitrite at low overpotentials is a challenging issue. Herein, using the combination of density functional theory and microkinetic modeling, we show that the selectivity for NH surpasses that of NO at -0.

Risk Factors for Weak Antibody Response of SARS-CoV-2 Vaccine in Adult Solid Organ Transplant Recipients: A Systemic Review and Meta-Analysis.

Objective: This is the first systematic review and meta-analysis to determine the factors that contribute to poor antibody response in organ transplant recipients after receiving the 2-dose severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine.

Method: Data was obtained from Embase, PubMed, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Chinese Biomedical Literature Database (CBM). Studies reporting factors associated with antibody responses to the 2-dose SARS-CoV-2 vaccine in solid organ transplant recipients were included in our study based on the inclusion and exclusion criteria.

Green Synthesis of Au-NPs on g-CN Hybrid Nanomaterials Based on Supramolecular Pillar[6]arene and Its Applications for Catalysis.

Gold nanoparticles (Au NPs) are installed in situ on the surfaces of graphitic carbon nitride (g-CN) based on supramolecular hydroxylatopillar[6]arene (P6). The Au NPs can be obtained via the redox reaction between HAuCl and P6 without any NH-NH, NaBH, and other reductants, where AuCl is reduced to Au by the -OH groups in the presence of OH, and the -OH groups are oxidized into -COOH. First, P6 is loaded onto the surface of g-CN via π-π interaction between P6 and g-CN, which offers a stabilized and reduced site for in situ anchoring of Au NPs.

MicroRNA-141-3p attenuates oxidative stress-induced hepatic ischemia reperfusion injury via Keap1/Nrf2 pathway.

Background: Hepatic ischemia reperfusion injury (IRI) is a major factor affecting the prognosis of liver transplantation through a series of severe cell death and inflammatory responses. However, the potential role of miR-141-3p in hepatic IRI is currently unknown.

Methods: We collected the serum of liver transplantation patients to study the relationship between miR-141-3p and liver injury.

Lipocalin2 as a useful biomarker for risk stratification in patients with acute cholangitis: A single-center prospective and observational study.

Background: Lipocalin2 (LCN2) is being increasingly used to diagnose and predict severe bacterial infection. We aimed to evaluate the predictive value of serum lipocalin 2 for severity grading of acute cholangitis (AC) on patient admission.

Methods: A total of 108 patients were enrolled in this study.

Neutrophil Extracellular Traps Regulate HMGB1 Translocation and Kupffer Cell M1 Polarization During Acute Liver Transplantation Rejection.

Neutrophil extracellular traps (NETs) play important roles in hepatic ischemic reperfusion injury (IRI) and acute rejection (AR)-induced immune responses to inflammation. After liver transplantation, HMGB1, an inflammatory mediator, contributes to the development of AR. Even though studies have found that HMGB1 can promote NET formation, the correlation between NETs and HMGB1 in the development of AR following liver transplantation has not been elucidated.

Localized Orbital Excitation Drives Bond Formation in Plasmonic Catalysis.

Localized surface plasmons generated on metallic nanostructures can be used to accelerate molecular transformations; however, the efficiency is limited by the challenge to control the energy/charge transfer at the interfaces. Here, we combine density functional theory (DFT) calculations and experiments to reveal the mechanism of nitrophenol reduction on Au nanoparticles under visible-light irradiation and propose a strategy to further enhance the reaction rates. DFT calculations show a reduced activation barrier under electronic excitation on Au(111), thus explaining the measured higher rates under visible-light irradiation.

CMPK2 accelerates liver ischemia/reperfusion injury via the NLRP3 signaling pathway.

Cytidine monophosphate kinase 2 (CMPK2) is a mitochondrial nucleotide monophosphate kinase which is important for the substrates of mitochondrial DNA synthesis and has been reported to participate in macrophage activation and the inflammatory response. The purpose of the present research was to determine the potential role of CMPK2 in hepatic ischemia/reperfusion (I/R) injury and to elucidate the underlying molecular mechanisms. The present study investigated the role of CMPK2 in regulating the NLRP3 pathway and liver dysfunction induced by hepatic I/R both and .

Advances in Electrochemical Ammonia Synthesis Beyond the Use of Nitrogen Gas as a Source.

Electrocatalytic reduction of dinitrogen has emerged as a new strategy for ammonia synthesis. Despite being environmentally benign and energy-saving, it suffers from low conversion efficiency and short yield of ammonia because of the challenges of activating the inert N≡N bond at room temperature and atmospheric pressure. As a result of this, researchers proposed to reduce the nitrogenous species, one category of air and water pollutants, into valuable ammonia.