Exosomal ANXA2 facilitates ovarian cancer peritoneal metastasis by activating peritoneal mesothelial cells through binding with TLR2.

Background: Peritoneal dissemination of ovarian cancer (OvCa) can be largely attributed to the formation of a metastatic microenvironment driven by tumoral exosomes. Here, we aimed to elucidate the mechanisms through which exosomal annexin A2 (ANXA2) derived from OvCa cells induces an HPMC phenotypic shift in favour of peritoneal metastasis.

Methods: Immunohistochemistry and orthotopic and intraperitoneal OvCa xenograft mouse models were used to clarify the relationship between tumour ANXA2 expression and peritoneal metastasis.

Ly6G Neutrophils and Interleukin-17 Are Essential in Protection against Rodent Malaria Caused by ANKA.

Neutrophils are essential in combating invading pathogens such as parasites, but the participation of their subpopulations and mechanisms in resistance to parasite infection are not fully understood. Our study identified a marked increase in Ly6G neutrophils in response to ANKA infection. Depletion of these cells rendered mice more susceptible to infection.

The relationship between physical activity and sleep quality among college students: The chain-mediating effects of self-control and mobile phone addiction.

The psychological and physiological health of undergraduates was correlated with the sleep quality, which can be improved through increasing physical activity. However, the correlations between physical activity and sleep quality are subject to various factors. In this study, we investigated the effects of self-control and mobile phone addiction on the correlations between physical activity on undergraduates' sleep quality at the psychological and behavioral levels.

New Polymeric Acceptors Based on Benzo[1,2-b:4,5-b'] Difuran Moiety for Efficient All-Polymer Solar Cells.

In order to realize high-performance bulk-heterojunction (BHJ) all-polymer solar cells, achieving appropriate aggregation and moderate miscibility of the polymer blends is one critical factor. Herein, this study designs and synthesizes two new polymer acceptors (Ps), namely PYF and PYF-Cl, containing benzo[1,2-b:4,5-b'] difuran (BDF) moiety with/without chlorine atoms on the thiophene side groups. Thanks to the preferred planar structure and high electronegativity of the BDF units, the resultant Ps generate strong intermolecular interactions and π-π stacking in both the neat and blend films.

Adolescent morphine exposure induced long-term cognitive impairment and prefrontal neurostructural abnormality in adulthood in male mice.

Opioids abuse in adolescence is becoming a pressing public health issue. While evidence suggests that exposure to opioids during adolescence leads to lasting alterations in brain development, the long-term cognitive implications in adulthood remain uncertain. We developed a male mouse model of adolescent morphine exposure and used the 5-choice serial reaction time task (5-CSRTT), along with the open field, novel object recognition, Y maze and Barnes maze tests, to assess changes in cognitive behavior.

Holographic communication using programmable coding metasurface.

With rapid development of holography, metasurface-based holographic communication scheme shows great potential in development of adaptive electromagnetic function. However, conventional passive metasurfaces are severely limited by poor reconfigurability, which makes it difficult to achieve wavefront manipulations in real time. Here, we propose a holographic communication strategy that on-demand target information is firstly acquired and encoded via a depth camera integrated with modified YOLOv5s target detection algorithm, then transmitted by software defined radio modules with long term evolution at 5 GHz, and finally reproduced in the form of holographic images by spin-decoupled programmable coding metasurfaces at 12 GHz after decoding through modified Gerchberg-Saxton algorithm.

Nerol attenuates doxorubicin-induced heart failure by inhibiting cardiomyocyte apoptosis in rats.

Background: As a broad-spectrum anti-tumour drug, the clinical application of DOX is often limited owing to its cardiotoxicity. Nerol is a naturally occurring compound with both anti-inflammatory and antioxidant properties. However, the ability of Nerol to improve DOX-induced heart failure and its underlying mechanisms remain unclear.

Development and mechanistic study of phosphate tailings based soil heavy metal prophylactic agents with encapsulated structure for lead stabilization and phosphorus speciation in soils.

The development of materials for the remediation of the environment from solid waste represents an effective utilization strategy. This study presents a novel phosphorus-based slow-release soil agent (SLPs) developed through acid activation of phosphorus tailings. SLPs aim to improve soil properties by gradually releasing phosphorus (P), reducing Pb mobility, and preventing heavy metal contamination.

The preoperative hemoglobin, albumin, lymphocyte, and platelet score (HALP) as a prognostic indicator in patients with non-small cell lung cancer.

Background: The Hemoglobin, Albumin, Lymphocyte, and Platelet score (HALP) is an inflammatory nutrition-related biomarker based on hemoglobin and albumin levels, as well as the lymphocyte and platelet load index, which has been reported to be associated with the prognosis of various types of tumors. This study aims to investigate the prognostic value of HALP in patients with non-small cell lung cancer (NSCLC).

Methods: A total of 2,428 patients with NSCLC were enrolled in the INSCOC study.

Stabilized Oxygen Vacancy Chemistry toward High-Performance Layered Oxide Cathodes for Sodium-Ion Batteries.

Anionic redox has emerged as a transformative paradigm for high-energy layered transition-metal (TM) oxide cathodes, but it is usually accompanied by the formation of anionic redox-mediated oxygen vacancies (OVs) due to irreversible oxygen release. Additionally, external factor-induced OVs (defined as intrinsic OVs) also play a pivotal role in the physicochemical properties of layered TM oxides. However, an in-depth understanding of the interplay between intrinsic and anionic redox-mediated OVs and the corresponding regulation mechanism of the dynamic evolution of OVs is still missing.

One-Step Electrochemical Modification of PEDOT:PSS/PBNPs Hybrid Hydrogel on the Screen-Printed Electrode Surface for Highly Sensitive Detection of Creatinine.

Creatinine (CRE) is frequently measured in clinical practice due to its recognized significance as a pivotal biomarker across a spectrum of renal and cardiovascular disorders. However, the rapid and accurate detection of CRE for assessing kidney and muscle functions remains challenging. Here, we prepared the poly(3,4ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) hydrogel uniformly loaded with Prussian blue nanoparticles (PBNPs) via a one-step metal-assisted electrochemical modification method on the screen-printed electrode for ultrasensitive CRE detection.

Human albumin infusion and risk of acute kidney injury in adults with nephrotic syndrome due to minimal change disease: A single-center retrospective study.

Background: The use of human albumin in patients with minimal change disease (MCD) remains controversial. The aim of the current study was to assess whether infusion of human albumin increased the risk of acute kidney injury (AKI) in adult patients with MCD.

Materials And Methods: Adult patients who underwent renal biopsy for the diagnosis of MCD at the center between 2017 and 2022 were screened.

An overview of phenylsulfonylfuroxan-based nitric oxide donors for cancer treatment.

Nitric oxide (NO) is a gaseous molecule integral to numerous physiological processes, including tumor modulation, cardiovascular regulation, and systemic physiological functions. Its dual role in promoting and inhibiting tumor growth makes it a focal point of contemporary oncological research. Phenylsulfonylfuroxan, a classical NO donor, has been shown to significantly elevate NO levels, thereby inducing apoptosis and inhibiting proliferation and metastasis in tumor cells.

Semen Cuscutae flavonoids activated the cAMP-PKA-CREB-BDNF pathway and exerted an antidepressant effect in mice.

Background: Semen Cuscutae flavonoids (SCFs) constitute a class of metabolites of Semen Cuscutae, a botanical drug that was recently found to have an anti-depression effect. This study aimed to evaluate the anti-depression effects of SCFs in chronic unpredictable mild stress (CUMS)-induced mice and to interrogate the underlying mechanisms.

Materials And Methods: The CUMS mice were used for assessing the effects of SCFs treatments on depression.

In vitro simulated digestion and Caco-2 cell absorption to explore potential of soy protein isolates as whey protein substitutes in canine and feline food.

Digestive properties and bioavailability of soy protein isolate and whey protein in canine and feline were evaluated using in vitro simulated digestion and cell absorption experiments. The amino acids and peptides in soybean protein isolate and whey protein after digestion were detected by high-performance liquid chromatography and liquid mass spectrometry. Gastrointestinal digestion rates of soy protein isolate and whey protein were analyzed by fitting digestive kinetics curves.

Covalent triazine based organic polymers modified ionization source for rapid and sensitive analysis of phytoestrogens.

The monitoring of phytoestrogen levels in food is essential for ensuring food safety; however, the low concentrations and complex matrices pose significant technical challenges. In this study, covalent triazine based organic polymers (TCOPs) was innovatively synthesized in situ on the surface of a steel substrate (TCOPs-S). These novel TCOPs-S were utilized as adsorbents for solid-phase microextraction and ionization sources in ambient mass spectrometry, enabling the rapid detection of phytoestrogens.

The safety and efficacy of regional citrate anticoagulation for multiple consecutive therapeutic plasma exchanges with fresh frozen plasma as a replacement solution.

Background: Therapeutic plasma exchange (TPE) is an important blood purification technology and most patients require multiple consecutive TPEs. Regional citrate anticoagulation (RCA) could be used for membrane therapeutic plasma exchange (mTPE). However, there is no research on the metabolic complications of the RCA for patients receiving multiple consecutive mTPEs with fresh frozen plasma (FFP) as a replacement solution.

Multiple instance learning method based on convolutional neural network and self-attention for early cancer detection.

Early cancer detection using T-cell receptor sequencing (TCR-seq) and multiple instances learning methods has shown significant effectiveness. We introduce a multiple instance learning method based on convolutional neural networks and self-attention (MICA). First, MICA preprocesses TCR-seq using word vectors and then extracts features using convolutional neural networks.

Inhibiting IP6K1 confers atheroprotection by elevating circulating apolipoprotein A-I.

Background And Aims: Atherosclerotic cardiovascular diseases are the leading cause of death. Apolipoprotein A-I (apoA-I) mediates cholesterol efflux to lower the risks of atherosclerosis. Elevating circulating apoA-I is an effective strategy for atheroprotection.

Multichannel full-space coding metasurface with linearly-circularly-polarized wavefront manipulation.

Achieving independent multitasked wavefront control by using an ultrathin plate is a challenge to increase information capacity in integration optics and radar applications. Transmission-reflection-integrated metasurface provides an efficient recipe primarily for multifunctional meta-device, however it is challenging to synergize both linear polarization (LP) and circular polarization (CP) using a single meta-plate. Here, a multichannel full-space coding metasurface composed of interleaved shared-aperture meta-atom is proposed to achieve large information capacity by capsulating judiciously engineered high efficiency triple sub-elements (modes) in four-layer scheme.

Precisely Constructing Superlattices of Soft Giant Molecules via Regulating Volume Asymmetry.

Soft matters, particularly giant molecular self-assembly, have successfully replicated complex structures previously exclusive to metal alloys. These superlattices are constructed from mesoatoms─supramolecular spherical motifs of aggregated molecules, and the formation of superlattices critically depends on the volume distributions of these mesoatoms. Herein, we introduce two general methods to control volume asymmetry (i.

Body Roundness Index Trajectories and the Risk of Cancer: A Cohort Study.

Background: The body rounds index (BRI), an innovative obesity indicator integrating waist circumference (WC) and height, offers a two-dimensional assessment of obesity. The relationship between BRI trajectories and cancer has been overlooked in previous studies. This study aims to explore the association between BRI trajectories and the incidence of cancer.

Intratumoral Transforming Boron Nanosensitizers for Amplified Boron Neutron Capture Therapy.

Boron neutron capture therapy (BNCT) is an advanced binary tumor-cell-selected heavy-particle radiotherapy used for treating invasive malignant tumors. However, its clinical applications have been impeded by the rapid metabolism and insufficient tumor-specific accumulation of boron agents. To tackle this issue, we develop a smart boron nanosensitizer (BATBN) capable of transforming its size in response to cancer biomarker for optimal balance between penetration and retention of boron-10 for BNCT.