Studies on curcumin and curcuminoids. XXXIX. Photophysical properties of bisdemethoxycurcumin.

The steady-state absorption and fluorescence, as well as the time-resolved fluorescence properties of bisdemethoxycurcumin dissolved in several solvents differing in polarity and H-bonding capability were measured. The photodegradation quantum yield of the compound in acetonitrile and methanol was determined. The bisdemethoxycurcumin decay mechanisms from the S(1) state were discussed and compared with those of curcumin.

Mucoadhesive microspheres for nasal administration of cyclodextrins.

The aim of this study was to examine the in vitro capacity of cyclodextrins to interfere on the beta-amyloid fibril formation; then, mucoadhesive microspheres containing cyclodextrins were prepared and characterised as nasal delivery system for brain targeting. Eight batches of microspheres containing chitosan or alginate loaded with beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin in two different cyclodextrin to polymer ratios were produced by spray drying. The results show that none of the tested CDs has direct cellular toxicity and they protect the cell viability from beta-peptide.