Publications by authors named "Ton V"
Article Synopsis
- Cardiogenic shock (CS) is a serious condition that can lead to severe complications, and this study looked at how changes in hemodynamic (blood flow-related) measurements correlate with patient outcomes in those suffering from heart failure or heart attack.
- Researchers analyzed data from over 2,200 patients to compare the hemodynamic profiles at the start and end of hospitalization, finding that mortality rates were higher in patients with acute myocardial infarction compared to those with heart failure.
- The study revealed that improvements in various hemodynamic and metabolic factors during hospitalization, such as lower blood pressure and better cardiac output, were linked to increased survival rates in both groups of patients.
Background: Transplantation using hearts obtained through donation after circulatory death (DCD) is increasing, but data on recipient renal outcomes are limited.
Methods And Results: Patients at a single institution who underwent heart transplantation using organs procured through DCD or donation after brain death (DBD) from April 2016 to August 2022 were included in this retrospective cohort study. Hemodynamic measures were collected via right heart catheterization performed 1 week after transplantation.
Article Synopsis
- The CSWG-SCAI staging system helps assess the severity of cardiogenic shock (CS) in patients, but there’s limited data on how these stages change over time and affect outcomes.
- This study analyzed data from 3,268 patients with acute myocardial infarction-related CS and heart failure-related CS to see how their SCAI stages changed over 72 hours.
- Findings showed that most patients’ stages changed within the first 24 hours, particularly those in stage B who had a high risk of worsening, indicating that early detection and ongoing evaluation are crucial for improving patient outcomes.
Article Synopsis
- A study analyzed data from 7,070 patients with cardiogenic shock (CS), finding that 5.6% developed acute limb ischemia (ALI), particularly among women and those with peripheral arterial disease.* -
- ALI incidence increased with the severity of CS, with highest rates among patients using advanced support devices like VA-ECMO and balloon pumps, yet less than half used distal perfusion catheters.* -
- Mortality rates were significantly higher for patients with ALI (57.4%) compared to those without (38.0%), highlighting ALI's severe impact on survival in CS patients.*
Life expectancy of patients with a durable, continuous-flow left ventricular assist device (CF-LVAD) continues to increase. Despite significant improvements in the delivery of care for patients with these devices, hemocompatability-related adverse events (HRAEs) are still a concern and contribute to significant morbility and mortality when they occur. As such, dissemination of current best evidence and practices is of critical importance.
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- The Impella 5.0 and 5.5 pumps are mechanical assist devices used in patients with severe cardiogenic shock (CS), but there is limited real-world data on their usage and outcomes.* -
- A study analyzed data from 6,205 patients across 34 hospitals, focusing on 754 who received Impella pumps between 2020-2023, with findings indicating that 32% used the Impella as the only device while 68% combined it with others.* -
- The overall survival rate for patients using Impella was 67%, with 20.4% achieving native heart recovery and 45.5% requiring heart replacement therapy; those with acute myocardial infarction had different outcomes compared
This paper addresses the management of patients' transportation requests within a hospital, a very challenging problem where requests must be scheduled among the available porters so that patients arrive at their destination timely and the resources invested in patient transport are kept as low as possible. Transportation requests arrive during the day in an unpredictable manner, so they need to be scheduled in real-time. To ensure that the requests are scheduled in the best possible manner, one should also reconsider the decisions made on pending requests that have not yet been completed, a process that will be referred to as rescheduling.
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- The study focused on comparing survival rates at discharge between women and men who experienced cardiogenic shock (CS) related to acute myocardial infarction (AMI) and heart failure (HF).
- Out of 5,083 CS patients, 1,522 were women, who showed worse survival rates and higher rates of vascular complications compared to men, particularly in the HF-CS group.
- The findings suggest that women are less likely to receive certain advanced treatments and may face unique challenges leading to poor outcomes, emphasizing the need for further research to improve their care.
Article Synopsis
- Consensus recommendations suggest transferring patients with cardiogenic shock (CS) from less equipped "spoke" centers to more advanced "hub" centers, but the outcomes of such transfers are not well understood outside specific health systems.
- The analysis, using data from a national registry including 15 U.S. sites, compared characteristics and outcomes of transferred patients versus those admitted directly to hub centers, focusing on acute myocardial infarction (AMI-CS) and heart failure-related cardiogenic shock (HF-CS).
- Results showed that 54.4% of enrolled patients were transferred, with transfer patients having higher mortality rates than nontransfer patients, primarily due to HF-CS; factors such as age and the need for advanced treatments were linked to increased mortality among
Chloroplasts are eukaryotic photosynthetic organelles that drive the global carbon cycle. Despite their importance, our understanding of their protein composition, function, and spatial organization remains limited. Here, we determined the localizations of 1,034 candidate chloroplast proteins using fluorescent protein tagging in the model alga Chlamydomonas reinhardtii.
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- Heart failure-related cardiogenic shock (HF-CS) is becoming more prevalent, and moderate/severe functional mitral regurgitation (FMR) in these patients is linked to poorer outcomes; the impact of the Impella device on hemodynamics with existing FMR wasn't previously studied.
- In a review of 24 patients who received an Impella 5.5 implant for HF-CS, 33% had moderate to severe FMR, and while some still had persistent FMR post-Impella, there was overall improvement in key hemodynamic parameters.
- The study concludes that although Impella may not reduce FMR severity acutely, it still significantly improves hemodynamic support within 24 hours, especially in patients with isolated
Article Synopsis
- Cardiogenic shock significantly contributes to deaths in patients experiencing acute myocardial infarction, with the study focusing on differences between those with ST-segment elevation myocardial infarction (STEMI-CS) and those with non-ST-segment elevation myocardial infarction (NSTEMI-CS).
- Among 1,110 patients analyzed, in-hospital mortality rates were high and similar for both groups, though those with out-of-hospital cardiac arrest had notably worse outcomes, especially in the NSTEMI-CS group.
- Despite the increase in the use of drugs and mechanical circulatory support during their hospital stay, the risk of in-hospital mortality remained elevated for both STEMI-CS and NSTEMI-CS patients, indicating a need for further research through
Background: Pulmonary artery catheters (PACs) are increasingly used to guide management decisions in cardiogenic shock (CS). The goal of this study was to determine if PAC use was associated with a lower risk of in-hospital mortality in CS owing to acute heart failure (HF-CS).
Methods And Results: This multicenter, retrospective, observational study included patients with CS hospitalized between 2019 and 2021 at 15 US hospitals participating in the Cardiogenic Shock Working Group registry.
The growing chicken industry in Viet Nam has an increasingly important contribution to the country's food security, but its development requires careful planning to prevent disease risks. This study characterizes the chicken production and distribution networks in Vietnam and identifies potential factors that could promote disease emergence and transmission. Qualitative data were collected from interviews with 29 key informants from five stakeholder groups representing the main nodes from chicken production and distribution networks (PDN).
View Article and Find Full Text PDFBackground: Donor organ demand continues to outpace supply in heart transplantation. Utilization of donation after circulatory death (DCD) hearts could significantly increase heart donor availability for patients with advanced heart failure.
Objectives: The purpose of this study was to describe hemodynamic and clinical profiles of DCD hearts in comparison to standard of care (SOC) hearts donated after brain death (DBD).
Introduction: Non-carious cervical lesions (NCCLs) can compromise the integrity to both hard and soft tissues of teeth. This case report introduces a novel interdisciplinary technique by utilizing bioceramics-based cement (BBC) and porcine collagen matrix (CM) to reconstruct the dentogingival complex where enamel, dentin, and soft tissues were involved.
Case Presentation: A 38-year-old healthy male was referred to the periodontics department for gingival recessions teeth #27-29 and a deep (NCCL) on the facial (F) #28 involving the loss of the cementoenamel junction (CEJ).
Left ventricular assist-device (LVAD) implantation is a life-saving therapy for patients with advanced heart failure (HF). With chronic unloading and circulatory support, LVAD-supported hearts often show significant reverse remodeling at the structural, cellular and molecular level. However, translation of these changes into meaningful cardiac recovery allowing LVAD explant is lagging.
View Article and Find Full Text PDFThe twelfth annual report from The Society of Thoracic Surgeons (STS) Interagency Registry for Mechanically Assisted Circulatory Support (Intermacs) highlights outcomes for 26 688 continuous-flow left ventricular assist device (LVAD) patients over the past decade (2011-2020). In 2020, we observed the largest drop in yearly LVAD implant volumes since the registry's inception, which reflects the effects of the COVID-19 pandemic on cardiac surgical volumes in the United States. The 2018 heart transplant allocation policy change in the United States continues to affect LVAD implantation volumes and device strategy, with 78.
View Article and Find Full Text PDFIntroduction: The SARS-CoV-2 virus that causes the COVID-19 disease is transmitted through the inhalation of droplets or aerosols and inoculation via the oronasal or ocular routes, transforming the management of swallowing disorders into a challenge for healthcare teams, given their proximity to the aerodigestive tract and the high probability of aerosol generation during patient evaluation and treatment.
Aim: To provide essential guidance for Latin American multidisciplinary teams, regarding the evaluation and treatment of oropharyngeal and esophageal dysphagia, at the different levels of healthcare. The position statement was formulated for the purpose of maintaining medical service continuity, in the context of a pandemic, and minimizing the propagation and infection risks of the virus.
Introduction: The SARS-CoV-2 virus that causes the COVID-19 disease is transmitted through the inhalation of droplets or aerosols and inoculation via the oronasal or ocular routes, transforming the management of swallowing disorders into a challenge for healthcare teams, given their proximity to the aerodigestive tract and the high probability of aerosol generation during patient evaluation and treatment.
Aim: To provide essential guidance for Latin American multidisciplinary teams, regarding the evaluation and treatment of oropharyngeal and esophageal dysphagia, at the different levels of healthcare. The position statement was formulated for the purpose of maintaining medical service continuity, in the context of a pandemic, and minimizing the propagation and infection risks of the virus.
There is an increasing concern about welfare issues related to battery cages, which are commonly used in Vietnam, and requires a modified cage that improves hen welfare while retaining its economic and management advantages. We combined adjacent conventional cages to form group cages to examine the effects of stocking density on egg production, economic returns, and aggressive pecking of hens. The control group included triplicate conventional cages with four birds/single cage (12 hens per three cages) or 450 cm area per hen.
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