Publications by authors named "Tomoyo Fujita"
Article Synopsis
- Researchers investigated herbal extracts for their ability to block T-type calcium channels (T-channels) linked to chronic pain, identifying sophoraflavanone G (SG) and its hop-derived analogues (2S)-6-prenylnaringenin (6-PNG) and (2S)-8-PNG as effective inhibitors.
- The active compounds showed varying potency against T-channels, with 6-PNG and 8-PNG demonstrating reversible inhibition in certain cellular models, while SG had a stronger effect overall.
- In animal studies, these compounds effectively reduced pain-related behaviors without significant side effects, suggesting their potential as therapeutic options for neuropathic and visceral pain.
Experience in early life can affect the development of the nervous system. There is now evidence that experience-dependent plasticity exists in adult insects. To uncover the molecular basis of plasticity, an invertebrate model, such as Drosophila melanogaster, is a powerful tool, as many established genetic and molecular methods can be applied.
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